• A Redesign for Yeast’s Genome, Chromosome by Chromosome - Jef Boeke, Weimin Zhang & Leslie Mitchell

  • Jun 28 2024
  • Length: 21 mins
  • Podcast

A Redesign for Yeast’s Genome, Chromosome by Chromosome - Jef Boeke, Weimin Zhang & Leslie Mitchell By cover art

A Redesign for Yeast’s Genome, Chromosome by Chromosome - Jef Boeke, Weimin Zhang & Leslie Mitchell

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  • Summary

  • To engineer yeast to do more, and understand genomes in general, Jef Boeke, Weimin Zhang (NYU Langone Health) and Leslie Mitchell (Neochromosome) have worked to replace yeast’s native chromosomes with synthetic versions. This project has turned out to be an international collaboration, with some artistic endeavors along the way. Eventually, the goal is to create an entirely human-generated yeast genome.

    Links from this episode:

    • Submit your own proposal to work with the JGI
    • Join us at the 2024 JGI User Meeting


    • Episode Transcript
    • Paper: Manipulating the 3D organization of the largest synthetic yeast chromosome
    • NYU Release: Researchers Assemble Nine Synthetic Yeast Chromosomes


    • Our contact info:
      • X: @JGI
      • Email: jgi-comms at lbl dot gov
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