Why do revolutionary ideas so often come from outsiders? Do good scientists sometimes crowd out great ones? Do we still have room for scientific cowboys? And what is the relationship between national security and modern science? Are scientists participants in a larger game they barely see? What if the most important ideas are the ones you’re not allowed to hear about? From Crick and Watson to nuclear bombs and AI, today we’ll cover it all with physicist, mathematician, and iconoclast Eric Weinstein.

Does brain science need a new grand plan? Is the brain less like an assembly line and more like a weather system? What does this mean for what counts as explanatory, and how might AI help us in the near future? What does any of this have to do with how the drug Ritalin got its name? Today we’ll speak with neuroscientist Nicole Rust, author of Elusive Cures.

Why do we believe what we believe? Why is changing our opinions so difficult, and why does a challenged belief so often feel like a personal attack? What if beliefs didn’t evolve to be true, but to be socially useful? Today we speak with Sam Harris about the topic of our beliefs: how we see the world and what we take to be true about it.

Is intelligence a property of individual brains, or is it something that emerges from many brains trying to align with one another? How can we build AI agents to improve our understanding of the world and to mediate between rivaling humans? For this and much more, we speak today with Danielle Perszyk, a cognitive scientist who leads the human-computer interaction team at Amazon’s AGI Lab.

What if your confidence in your political beliefs does not correlate with their accuracy? Why does a pundit's outrage often feel so convincing and nuance so unsatisfying? Are conspiracy theories a predictable feature of human brains? Is there any way to stop ourselves from mistaking our feelings for conclusions? How can we come to be clearer thinkers? Today we speak with political commentator Kaizen Asiedu about how we arrive at our hot takes on the world.

Medications are among the most important advancements of science, but their social consequences are often complex. What if some of our most common diseases are design flaws of modern life? Does it matter if we're fixing a root cause rather than just circumventing it? If a pill can quiet hunger, pain, or anxiety, is that "cheating"? Today we talk about the fascinating world of prescription drugs with science journalist Thomas Goetz.

What does it mean for your life to matter? We all talk a lot about happiness, pleasure, and meaning... but what if the real engine underneath it all is the need to feel we count? Is it possible that depression, extremism, and ambition all stem from the same psychological source? When is political polarization less about beliefs and more about threatened significance? Join Eagleman with philosopher and writer Rebecca Goldstein, author of "The Mattering Instinct".

What exactly is hypnosis? We’ve all heard of circus-like versions, but is there a real element to hypnosis that psychiatrists and neuroscientists are able to leverage? Can attention and expectation change what we feel (such as pain or anxiety)? What do suggestible states reveal about the brain’s pathways? How does hypnosis compare to meditation, flow states, or psychedelic drugs? Today we speak with David Spiegel, Stanford psychiatrist and one of the world’s experts in hypnosis.