• Let there be Light: Optical Recording Part I

  • Apr 11 2022
  • Length: 1 hr and 29 mins
  • Podcast

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Let there be Light: Optical Recording Part I

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  • Welcome back to Neurotech Pub! This episode is one of a two part series on optical methods for recording and stimulating neural activity. Our guests on this episode are Elizabeth Hillman, PhD,  Mark Schnitzer, PhD, and Jacob Robinson, PhD. So far, our technical dives have focused mainly on direct electrical recording and stimulation of neural activity, but in this episode we deep dive into advantages that all-optical interfaces might have over electrical interfaces, and the challenges in developing them. In addition, we talk about running highly collaborative, interdisciplinary projects that span traditional physics and engineering with biology, a theme that is ever-present in neurotech and is also highlighted in part two of this series. Cheers!Check out full video with transcript here: https://www.paradromics.com/podcast/episode-11-let-there-be-lightShow NotesLatest news & publications since recording: >> Hillman Lab: New publication on SCAPE in Nature Biomedical Engineering>> Robinson Lab: Review article in Optica on Recent advances in lensless imaging>> Robinson Lab: BioRxiv pre-print on in vivo fluorescence imaging1:23 | The Heart and Soul of a Paper2:32| Ultrasmall Mode Volumes in Dielectric Optical Microcavities3:01 | Robinson Lab4:01 | Hillman Lab4:07 | Zuckerman Institute4:15 | Schnitzer Lab4:25 | Howard Hughes Medical Institute4:41| Miniature Fluorescence Microscope9:02 | Discovery of DNA Structure and Function10:25 | Hodgkin–Huxley Equations13:49 | Vessel Dilation in the Brain16:03 | State of the art of Neural Optical Recording18:03 | Long-Term Optical Access to an Estimated One Million Neurons in Mouse Cortex24:56 | Watch the Crystal Skull video27:45 | High-Speed Cellular-Resolution Light Beads Microscopy29:54 | Relationship between spiking activity and calcium imaging32:50 | Analytical & Quantitative Light Microscopy [AQLM]32:59 | Imaging Structure & Function in the Nervous System35:22 | NIH Brain Initiative Cell Census Network (BICCN)35:54 | Allen Brain Atlas: Cell Types40:17 | A Theory of Multineuronal Dimensionality, Dynamics and Measurement46:19 | Dr. Laura Waller's DIY Diffuser Cam50:38 | FlatCam by Robinson Lab53:42 | Advantages of MEG55:06| Random Access Two Photon Scanning Techniques56:07 | Swept Confocally-Aligned Planar Excitation (SCAPE)58:47 | Optics Systems for Implantable BCIs1:00:43 | GCaMP - Janelia GECI reagents1:01:33 | DARPA NESD Program1:04:06 | SCAPE Microscopy for High-Speed Volumetric Imaging of Behaving Organisms1:07:00 | Glial Response to Implanted Electrodes1:07:07 | Brain Tissue Responses to Neural Implants1:09:36 | Two Deaths in Gene Therapy Trial for Rare Muscle Disease1:10:46 | Intrinsic Optical Signal due to Blood Oxygenation1:11:11 | Coupling Mechanism and Significance of the BOLD Signal1:12:10 | DARPA invests in Treating Mood Disorders1:12:57 | Amygdalar Representations of Pain1:13:48 | Fast Optical Signals: Principles, Methods, and Experimental Results1:14:12 | Dr. Larry Cohen's early work in Neurophotonics1:14:42 | Linear Systems Analysis of Functional Magnetic Resonance Imaging | Additional Resource1:16:20 | Flavoprotein Fluorescence Imaging in Neonates | Additional Resource1:18:02 | Pumped Probe Microscopy1:19:26 | Biological Imaging of Chemical Bonds by Stimulated Raman Scattering Microscopy1:19:36 | Coherent Anti-Stokes Raman Scattering microscopy (CARS)1:19:55 | Min Lab @ Columbia1:20:06 | Glucose Analog for Stimulated Raman Scattering1:20:39 | Emerging Paradigms for Aspiring NeurotechnologistsWant more? Follow Paradromics & Neurotech Pub on Twitter  Follow Matt, Elizabeth, Jacob & Mark 
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