Sam Harris speaks with Dr. Jennifer Mitchell and Dr. Sarah Abedi about recent developments in research on psychedelics. They discuss the history of this research and the war on drugs, recent setbacks in the FDA approval process, MDMA as a treatment for post-traumatic stress disorder (PTSD), the challenges of conducting this research, allegations of therapist misconduct, new therapeutic models for mental health treatment, psychoneuroimmunology, "non-psychedelic" psychedelics, good and bad trips, the FDA's coming decision on MDMA-assisted therapy, "right-to-try" policies for pharmaceuticals, the role of psychedelic therapists, the problem of having all this therapeutic work being done underground, and other topics.

Petition to approve MDMA-assisted therapy for PTSD: https://www.approvemdmatherapy.com/

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Learning how to train your mind is the single greatest investment you can make in life. That’s why Sam Harris created the Waking Up app. From rational mindfulness practice to lessons on some of life’s most important topics, join Sam as he demystifies the practice of meditation and explores the theory behind it.

Sam Harris and Anne Applebaum discuss the nature of modern autocracies and how democracies fail. They discuss the power of ideas, why autocracies seek to undermine democracies, cooperation among dictators, how Western financial experts and investors have enabled autocracies, how Putin came to power, the failure of engagement and investment to create political change, what’s at stake in the war in Ukraine, Trump’s charisma, the current symptoms of American democratic decline, the ideologues around Trump, the hollowing out of institutions, how things might unravel in America, anti-liberal tendencies in American politics, the role of social media, the different pathologies on the Left and Right, analogies to Vichy France, the weakness of the Democrats, the political effects of the assassination attempt on former President Trump, and other topics.

If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.

If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.

Sam Harris speaks with Christof Koch about the nature of consciousness. They discuss Christof’s development as a neuroscientist, his collaboration with Francis Crick, change blindness and binocular rivalry, sleep and anesthesia, the limits of physicalism, non-locality, brains as classical systems, conscious AI, idealism and panpsychism, Integrated Information Theory (IIT), what it means to say something “exists,” the illusion of the self, brain bridging, Christof’s experience with psychedelics, and other topics.

If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.

Learning how to train your mind is the single greatest investment you can make in life. That’s why Sam Harris created the Waking Up app. From rational mindfulness practice to lessons on some of life’s most important topics, join Sam as he demystifies the practice of meditation and explores the theory behind it.

Sam Harris speaks with Michal Cotler-Wunsh about the global rise of antisemitism. They discuss the bias against Israel at the United Nations, the nature of double standards, the precedent set by Israel in its conduct in the war in Gaza, the shapeshifting quality of antisemitism, anti-Zionism as the newest strain of Jew hatred, the “Zionism is racism” resolution at the U.N., the lie that Israel is an apartheid state, the notion that Israel is perpetrating a “genocide” against the Palestinians, the Marxist oppressed-oppressor narrative, the false moral equivalence between the atrocities committed by Hamas and the deaths of noncombatants in Gaza, the failure of the social justice movement to respond appropriately to events in Israel, what universities should have done after October 7th, reclaiming the meanings of words, extremism vs civilization, and other topics.

If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.

Sam Harris speaks with George Saunders about his creative process. They discuss George’s involvement with Buddhism, the importance of kindness, psychedelics, writing as a practice, the work of Raymond Carver, the problem of social media, our current political moment, the role of fame in American culture, Wendell Berry, fiction as way of exploring good and evil, The Death of Ivan Ilyich, missed opportunities in ordinary life, what it means to be a more loving person, his article “The Incredible Buddha Boy,” the prison of reputation, Tolstoy, and other topics.

If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.

Learning how to train your mind is the single greatest investment you can make in life. That’s why Sam Harris created the Waking Up app. From rational mindfulness practice to lessons on some of life’s most important topics, join Sam as he demystifies the practice of meditation and explores the theory behind it.

Sam Harris speaks to Bill Maher about the state of the world. They discuss the aftermath of October 7th, the cowardice and confusion of many celebrities, gender apartheid, the failures of the Biden campaign, Bill’s relationship to his audience, the differences between the left and right, Megyn Kelly, loss of confidence in the media, expectations for the 2024 election, the security concerns of old-school Republicans, the prospect of a second Trump term, totalitarian regimes, functioning under medical uncertainty, Bill’s plan to stop doing stand-up (maybe), looking back on his career, his experience of fame, Jerry Seinfeld, and other topics.

If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.

Learning how to train your mind is the single greatest investment you can make in life. That’s why Sam Harris created the Waking Up app. From rational mindfulness practice to lessons on some of life’s most important topics, join Sam as he demystifies the practice of meditation and explores the theory behind it.

In today’s housekeeping, Sam explains his digital business model. He and Yasmine Mohammed (co-host) then speak with Masih Alinejad about gender apartheid in Iran. They discuss the Iranian revolution, the hypocrisy of Western feminists, the morality police and the significance of the hijab, the My Stealthy Freedom campaign, kidnapping and assassination plots against Masih, lack of action from the U.S. government, the effect of sanctions, the cowardice of Western journalists, the difference between the Iranian population and the Arab street, the unique perspective of Persian Jews, Islamism and immigration, the infiltration of universities, and other topics.

If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.