Why do humans get cardiovascular disease and how can we prevent it? These are critical processes to understand for anyone who is interested in living a longer and healthier life. I'm very honored to talk with Dr. Tom Dayspring, a world-renowned clinical lipidologist and physician whose topic expertise is unparalleled. We discuss the underlying process of atherosclerosis & the formation of plaques, ApoB, methods to stabilize plaque, metabolic syndrome and insulin resistance, markers and the risk of atherosclerosis, LP-PLA2 & atherosclerosis, homocysteine and cardiac risk, genetic therapies for lipid disorders. We also discuss lifestyle interventions, including exercise, in managing lipid disorders and reducing cardiovascular risk. Dr. Dayspring Twitter: https://x.com/Drlipid Chapters: 01:07 Introduction 07:44 ApoB & Atherosclerosis 13:25 How Plaques Form 26:32 Stabilizing Plaque & Preventing Rupture 31:46 Metabolic Syndrome & Insulin Resistance 37:57 Markers & Risk of Atherosclerosis 40:42 LP-PLA2 & Atherosclerosis 47:00 Homocysteine & Cardiac Risk 57:14 Genet Therapies for Lipid Disorders 01:09:50 The Role of Exercise Social & Website: Instagram - / sterlingmdphd Twitter - / sterlingmdphd Facebook - / sterlingmdphd TikTok - / sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Subscribe to the Podcast: Apple Podcasts: https://apple.co/3y438C9 Spotify: https://open.spotify.com/show/5TDUK3F... Google Podcasts: https://bit.ly/3Olanei References & Show Notes: http://www.nicksterling.com/ The content of this podcast is not medical advice, is for general information purposes only, and does not constitute the practice of medicine or any other healthcare professional services. No doctor-patient relationship is formed. The content of this podcast is not a substitute for medical evaluation or treatment and does not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.

In this episode, I had the pleasure of sitting down with Nicolas Verhoeven of Physionic. We focus our attention on metabolic health and, specifically, the energy-related, cellular, and nutritional mechanisms of insulin resistance. Nicolas reviews evidence pertaining to the reversal of insulin resistance and dietary clinical trials demonstrating remission of type 2 diabetes. Nicolas also highlights the synergistic effects of physical activity and dietary habits on insulin resistance, expanding our discussion into mitochondrial health. Finally, we explore importance of a nuanced conversation around autophagy and its role in health and disease prevention. Physionic on YouTube: https://www.youtube.com/@Physionic Chapters: 00:00:13 - Nicolas' Background & Inspiration 00:05:34 - Misconceptions about Carbs & Fat Intake 00:08:57 - Mechanisms of Insulin Resistance 00:18:34 - Reversing Insulin Resistance & Diabetes 00:23:08 - Measuring Insulin Resistance 00:24:20 - Continuous Glucose Monitoring (CGM) 00:30:25 - Insulin Resistance & Health 00:37:33 - Mitochondrial Dysfunction 00:49:14 - Mitochondrial Biogenesis 00:56:05 - Improving Mitochondrial Health 01:02:54 - Autophagy 01:07:28 - Closing Remarks Social & Website: Instagram - https://www.instagram.com/sterlingmdphd Twitter - https://twitter.com/sterlingmdphd Facebook - https://www.facebook.com/sterlingmdphd TikTok - https://www.tiktok.com/@sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Subscribe to the Podcast: Apple Podcasts: https://apple.co/3y438C9 Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c Google Podcasts: https://bit.ly/3Olanei References & Show Notes: http://www.nicksterling.com/ The content of this podcast is not medical advice, is for general information purposes only, and does not constitute the practice of medicine or any other healthcare professional services. No doctor-patient relationship is formed. The content of this podcast is not a substitute for medical evaluation or treatment and does not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.

In this episode, we discuss polarized training, which includes high-volume low intensity training and high-intensity training. We review the scientific literature pertaining to endurance performance, mechanisms of recovery debt, adaptations to various exercise modalities, and developing training programs around polarized training.

MAF-180: https://philmaffetone.com/180-formula/

#ultra #ironman #endurance #fitness #marathon

Chapters:

00:00 - Intro

01:20 - Athletic Burnout

02:36 - Endurance Training Distributions

03:37 - Recovery Debt

04:06 - Exercise-Induced Cardiac Fatigue

04:34 - Nervous System Fatigue

05:33 - Muscle Microtrauma

07:01 - Fitness Adaptations

08:56 - Maximum Aerobic Heart Rate

10:30 - Lactate Threshold

11:04 - High Intensity Exercise

11:57 - Polarized Training Program

13:05 - Outro

Social & Website:

Newsletter: http://eepurl.com/hQpdqT

Instagram: https://www.instagram.com/sterlingmdphd

Twitter: https://twitter.com/sterlingmdphd

Facebook: https://www.facebook.com/sterlingmdphd

TikTok - https://www.tiktok.com/@sterlingmdphd

Subscribe to the Podcast:

Apple Podcasts: https://apple.co/3y438C9

Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c

Google Podcasts: https://bit.ly/3Olanei

References & Show Notes:

http://www.nicksterling.com/

Does muscle loss occur in people taking GLP-1 receptor agonists such as semaglutide (marketed as "Ozempic" and "Wegovy") or combined GLP-1/GIP agonists like tirzepatide (marketed as "Mounjaro")? In this episode, we discuss current evidence regarding these next-generation weight loss drugs and muscle wasting, as well as principles of preventing muscle loss in weight loss programs. #healthspan, #ozempic, #fitness, #muscle, #science Chapters: 00:00 - Intro 00:30 - Importance of Muscle in Weight Loss 01:19 - Muscle Loss During Weight Loss 02:03 - What Affects Muscle Mass During Weight Loss? 02:16 - Clinical Trials 04:59 - Preserving Muscle During Weight Loss 05:30 - Protein Intake 06:28 - Strength Training 06:59 - Monitoring Body Composition 07:26 - Summary Social & Website: Instagram - https://www.instagram.com/sterlingmdphd Twitter - https://twitter.com/sterlingmdphd Facebook - https://www.facebook.com/sterlingmdphd TikTok - https://www.tiktok.com/@sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Subscribe to the Podcast: Apple Podcasts: https://apple.co/3y438C9 Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c Google Podcasts: https://bit.ly/3Olanei References & Show Notes: http://www.nicksterling.com/ The content of this video is for general information purposes only and does not constitute the practice of medicine or any other healthcare professional services. The content of this video is not medical advice. No doctor-patient relationship is formed. The content of this video should not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.

How do drugs like Ozempic (semaglutide) cause weight loss? In this episode, we discuss how these drugs (GLP-1 receptor agonists) target specific areas in the brain to suppress appetite and facilitate weight loss. We also discuss clinical trials data suggesting that these drugs and/or the weight loss that they facilitate may have cardioprotective effects. Lastly, we will also examine evidence regarding weight regain when coming off of these drugs and common side effects. Link to episode on neuroscience of appetite regulation: https://www.youtube.com/watch?v=i3RzV9vS_FA#healthspan, #semaglutide, #ozempic, #wegovy, #science, #weightloss Chapters: 00:00 - Intro 01:31 - What Does GLP-1 Do? 02:08 - GLP-1 Receptors in the Brain 02:52 - Activating the GLP-1 "Switch" (Receptors) 04:13 - Clinical Trials - Semaglutide for Weight Loss 05:29 - Semaglutide and Heart & Metabolic Health 05:54 - For How Long Does Semaglutide Work? 06:35 - Weight Regain After Stopping Semaglutide 08:24 - Side Effects of GLP-1 Receptor Agonists 09:37 - Take-Home Points 10:20 - Outro Social & Website: Instagram - https://www.instagram.com/sterlingmdphd Twitter - https://twitter.com/sterlingmdphd Facebook - https://www.facebook.com/sterlingmdphd TikTok - https://www.tiktok.com/@sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Subscribe to the Podcast: Apple Podcasts: https://apple.co/3y438C9 Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c Google Podcasts: https://bit.ly/3Olanei References & Show Notes: http://www.nicksterling.com/ The content of this video is for general information purposes only and does not constitute the practice of medicine or any other healthcare professional services. The content of this video is not medical advice. No doctor-patient relationship is formed. The content of this podcast should not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.

Highly processed foods have been shown to lead to weight gain and are thought to drive intake through several mechanisms. Recent research suggests that the effect of combining fats and carbs on appetite might be more than the sum of their individual effects. Highly processed foods, accordingly, might simulate increased intake via the ratio of macronutrients. Link to episode on neuroscience of appetite regulation: https://www.youtube.com/watch?v=i3RzV9vS_FA Study Link: https://doi.org/10.1016/j.cmet.2018.06.010 Errata: Hu et al. was published in 2018. #diet, #weightloss, #science, #fitness, #food Chapters: 00:00 Intro to Ultra-Processed Foods 00:51 Mouse Study on Macronutrients & Food Intake 01:34 Fat-to-Carb Ratio May Affect Food Intake 02:15 Brain Effects of Diet 03:26 Key Points 03:51 Study Limitations 04:23 Outro Social & Website: Instagram - https://www.instagram.com/sterlingmdphd Twitter - https://twitter.com/sterlingmdphd Facebook - https://www.facebook.com/sterlingmdphd TikTok - https://www.tiktok.com/@sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Subscribe to the Podcast: Apple Podcasts: https://apple.co/3y438C9 Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c Google Podcasts: https://bit.ly/3Olanei References & Show Notes: http://www.nicksterling.com/ The content of this video is for general information purposes only and does not constitute the practice of medicine or any other healthcare professional services. The content of this video is not medical advice. No doctor-patient relationship is formed. The content of this podcast should not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.

Growing scientific evidence suggests that highly processed foods are associated with increased risk of disease. Until recently, scientists were unable to study directly the effects of highly processed foods on humans. In this episode, we review one of the first highly controlled scientific trials demonstrating that ultra-processed foods lead to weight gain. 

Neuroscience of appetite regulation: https://youtu.be/i3RzV9vS_FA

#diet, #weightloss, #science, #fitness, #food

Chapters:

00:00 - Intro to Ultra-Processed Foods

00:55 - What are Ultra-Processed Foods?

02:14 - Disease & Ultra-Processed Foods

03:19 - Interventional Study

04:24 - Ultra-Processed Foods & Weight Gain

05:44 - Take-Home Points

06:57 - Outro

Social & Website:

Instagram - https://www.instagram.com/sterlingmdphd

Twitter - https://twitter.com/sterlingmdphd

Facebook - https://www.facebook.com/sterlingmdphd

TikTok - https://www.tiktok.com/@sterlingmdphd

Newsletter - http://eepurl.com/hQpdqT

Subscribe to the Podcast:

Apple Podcasts: https://apple.co/3y438C9

Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c

Google Podcasts: https://bit.ly/3Olanei

References & Show Notes:

http://www.nicksterling.com/

In this episode, we discuss how overeating can lead to inflammation and neuron dysfunction in specific parts of the brain that control appetite and energy regulation. We review the neuroscience of appetite regulation, energy expenditure, and body fat regulation. Topics include hypothalamic dysfunction of body fat regulation, leptin resistance, neuro-inflammation, and physical changes in the hypothalamus involving microglia (the immune cells of the brain). We also review what is known about avoiding and reversing these changes.

Chapters:

00:00:00 - Introduction
00:00:37 - Brain Changes in Obesity
00:01:20 - Leptin Deficiency & Obesity
00:03:25 - Leptin Replacement
00:04:43 - Hypothalamic Obesity
00:05:42 - What is the Hypothalamus?
00:06:51 - Food Intake, Appetite, & VMH
00:08:50 - Ob Gene
00:09:34 - The Satiety Factor
00:11:11 - Leptin Paradox
00:11:51 - Leptin Resistance
00:13:41 - Leptin Physiology
00:15:03 - Leptin Resistance
00:18:11 - Effects of Leptin Resistance
00:18:29 - Improving Leptin Resistance
00:20:24 - Hypothalamic Inflammation
00:24:08 - Triggers of Hypothalamic Inflammation
00:25:45 - Fatty Acids & Hypothalamic Inflammation
00:26:24 - Advanced Glycation End Products (AGEs)
00:27:05 - Current Knowledge on Hypothalamic Inflammation
00:28:17 - Summary
00:30:16 - Outro

Social & Website:

Instagram - https://www.instagram.com/sterlingmdphd 

Twitter - https://twitter.com/sterlingmdphd

Facebook - https://www.facebook.com/sterlingmdphd

TikTok - https://www.tiktok.com/@sterlingmdphd

Newsletter - http://eepurl.com/hQpdqT

Subscribe to the Podcast:

Apple Podcasts: https://apple.co/3y438C9

Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c

Google Podcasts: https://bit.ly/3Olanei

References & Show Notes:

http://www.nicksterling.com/