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In this week’s episode of On The Pen Live, guest Scott Liberto of PlanetScott.com joins to discuss his experience in the Survodutide clinical trial.

Survodutide is an investigational dual agonist targeting both the glucagon and GLP-1 receptors, developed by Boehringer Ingelheim in collaboration with Zealand Pharma. This novel drug is designed to treat obesity and metabolic dysfunction-associated steatohepatitis (MASH).

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SHOW LINKS:
Novo Nordisk fire:
Link: https://www.wsj.com/livecoverage/stock-market-today-dow-jones-earnings-05-16-2024/card/fire-at-novo-nordisk-construction-site-gives-investors-a-scare-eSSAtdDDhxYwUw3bGDZI?mod=lctimeline_finance

New CagriSema drug trial
Link: https://clinicaltrials.gov/study/NCT06409130

Wegovy Heart Benefits:
Link: https://www.cnn.com/2024/05/13/health/wegovy-trial-analysis/index.html

CT-488 Phase 1 Results:
Link: https://www.fiercebiotech.com/biotech/roches-27b-carmot-bet-pays-phase-1-weight-loss-success

Nothing contained in this podcast is medical advice. Please consult your liscensed physician on all matters pertaining to your health. Any Amazon links are affiliate links, which provide a small percentage of any sale to me as a commission.

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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit my website at onthepen.com. You can also connect with me on social media, where I go by @manonthemounjaro (or @manonmounjaro on X). Let's continue this journey together towards a healthier and happier life!

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SHOW NOTES:
Update on Bernie Sander's fight against high prices for GLP-1 medicationsLink: https://www.msn.com/en-us/health/other/novo-asks-for-more-time-to-answer-sanders-on-ozempic-s-price/ar-BB1lZ0P2

CFO of Viking Therapeutics sold stock
Link: https://www.investing.conews/company-news/viking-therapeutics-cfo-sells-over-49-million-in-company-stock-93CH-3419573

Novo Nordisk bond sale (Bloomberg article):
Link: https://www.bloomberg.com/news/articles/2024-05-13/ozempic-maker-novo-nordisk-plans-bond-sale-to-fund-expansion?embedded-checkou

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Roche Pharmaceuticals has acquired Carmot Therapeutics along with three obesity and type 2 diabetes candidates: CT-868 / CT-368 / CT-986

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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit my website at onthepen.com. You can also connect with me on social media, where I go by @manonthemounjaro (or @manonmounjaro on X). Let's continue this journey together towards a healthier and happier life!

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LINKS
Life Update Blog: Link: https://www.onthepen.com/post/i-m-tired-we-are-tired

Wegovy released in Canada:
Link: https://www.msn.com/en-ca/health/other/weight-loss-drug-wegovy-available-in-canada-starting-may-6/ar-AA1o1lZz

Madison Muller at Bloomberg (friend of our community) had article "Why Weight-Loss Drugs Wegovy, Zepbound Are in Short Supply"
Link: https://www.bloomberg.com/news/articles/2024-05-02/why-weight-loss-drugs-wegovy-zepbound-are-facing-shortages?srnd=undefined&embedded-checkout=true

Interviewed on radio station KXEL
Link: https://www.youtube.com/watch?v=V0YyMwtMuxs

Optum RX Irony alert:
Link: https://www.managedhealthcareexecutive.com/view/glp-1-tiering-agreement-reached-says-optum-rx-president

FTC is challenging Novo Nordisk's patents on Ozempic
Link: https://www.ftc.gov/system/files/ftc_gov/pdf/novo-nordisk-ozempic-saxenda-victoza-_4302024.pdf

FTC requested additional information on Novo Nordisk's acquisition of Catalent:
Link: https://www.msn.com/en-us/money/markets/us-ftc-seeks-more-information-on-novo-nordisk-parent-catalent-deal/ar-AA1o6gHU

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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit my website at onthepen.com.

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Dave Knapp does a deep dive into todays Eli Lilly earnings call.

https://www.onthepen.com/post/zepbound-vial-watch-eli-lilly-earnings-q1-2024

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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit my website at onthepen.com. You can also connect with me on social media, where I go by @manonthemounjaro (or @manonmounjaro on X). Let's continue this journey together towards a healthier and happier life!

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1.7 mg of Wegovy is no longer in shortage:
Semaglutide: FDA website updated to show 1.7 mg of Wegovy is no longer in shortage
Link: https://www.accessdata.fda.gov/scripts/drugshortages/dsp_ActiveIngredientDetails.cfm?AI=Semaglutide%20Injection&st=c

GNC introduces special section for GLP-1 users:
GNC will have special section for GLP-1 users that will concentrate on four areas: GI Health, Retaining Lean muscle mass, Bone health, Nutritional support
Link: https://www.gnc.com/learn/newsroom/gnc-semaglutide-support-program.html

Identified upper dose values in tirzepatide high-dose trial
20 mg and 25 mg
Primary Completion in this trial is 12/24/2024 (Merry Christmas) with final completion September 30, 2025
Link: https://www.onthepen.com/post/higher-doses-of-zepbound-and-mounjaro-being-tested

US Senator Bernie Sanders investigating the price of Wegovy/Ozempic
Ozempic costs $936 per month, while Wegovy costs $1,350
Ozempic costs $155 in Canada, and cost $59 in Germany. This dramatic difference in cost has led to concerns about the accessibility and affordability of these drugs for American patients.
With the cardiovascular disease indication, millions of additional medicare patients are eligible for taking Wegovy which means billions at the current prices
Link: https://www.onthepen.com/post/the-price-of-health-bernie-sanders-investigates-ozempic-and-wegovy
Link: https://www.kff.org/medicare/issue-brief/a-new-use-for-wegovy-opens-the-door-to-medicare-coverage-for-millions-of-people-with-obesity/

Germany is promoting their pharmaceuticals industry:
tax breaks, and speeding up clinical trials
Eli Lilly is investing 2.3 Billion Euros to build a glp-1 manufacturing plant in Germany:
Link: https://uk.finance.yahoo.com/news/scholz-promises-support-pharma-sector-101833297.html

Lexaria begins phase 1 trial:
Lexaria (stock symbol: LEXX) will test their technology to improve stomach absorption of Rybelsus in phase 1 trial (i.e. wouldn't need large 25/50 mg doses if absorption was better).
They are also testing under tongue (sublingual) absorption of Rybelsus in another phase 1 trial
Link: https://ir.lexariabioscience.com/news-events/press-releases/detail/246/lexaria-receives-ethics-review-board-approval-to-begin-new

Viking Therapeutics earnings call
Planning to start addition phase 2 trial of injectable VikingTide (VK2735) in Q4 of 2024 that will last 6-9 months (If you remember, the first phase 2 trial was only 13 weeks)
The oral VikingTide (VK2735) phase 1 trial is still investigating higher and higher doses due to the low side effect profile. They expect results in summer of 2024.


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New obesity medicine company launches, Lilly expands manufacturing capacity with acquisition, and TikTok censors my content.

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New Obesity Medicine Company Launches: https://metsera.com/news
Lilly Acquires Nexus Facility: https://finance.yahoo.com/news/lilly-buy-injectable-drug-plant-175000782.html
TikTok Mounjaro Zepbound Censorship: https://www.bloomberg.com/news/articles/2024-04-22/tiktok-ozempic-influencers-say-new-rules-unfairly-target-them

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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit my website at onthepen.com. You can also connect with me on social media, where I go by @manonthemounjaro (or @manonmounjaro on X). Let's continue this journey together towards a healthier and happier life!