We meet Paul Garner (prof. emerit. and one of the founding fathers of Cochrane) and Rebecca Kuehn (Cochrane infectious diseases) for a talk about evidence-based medicine, critical appraisal and all things related to how we interpret and find the "truth" within research.

Resources:

1.Ioannidis JP. Why most published research findings are false. PLoS Med. 2005;2(8):e124.

2.Garner P, Taylor-Robinson D, Sachdev HS. DEVTA: results from the biggest clinical trial ever. Lancet. 2013;381(9876):1439-41.

3.Gigerenzer G. Making sense of health statistics. Bull World Health Organ. 2009;87(8):567.

4.https://www.badscience.net/2010/07/yeah-well-you-can-prove-anything-with-science/

5.de Souza DK, Thomas R, Bradley J, Leyrat C, Boakye DA, Okebe J. Ivermectin treatment in humans for reducing malaria transmission. Cochrane Database Syst Rev. 2021;6(6):CD013117.

6.Foy BD, Alout H, Seaman JA, Rao S, Magalhaes T, Wade M, et al. Efficacy and risk of harms of repeat ivermectin mass drug administrations for control of malaria (RIMDAMAL): a cluster-randomised trial. Lancet. 2019;393(10180):1517-26.

7.Popp M, Reis S, Schiesser S, Hausinger RI, Stegemann M, Metzendorf MI, et al. Ivermectin for preventing and treating COVID-19. Cochrane Database Syst Rev. 2022;6(6):CD015017.

8.Hadinegoro SR, Arredondo-Garcia JL, Capeding MR, Deseda C, Chotpitayasunondh T, Dietze R, et al. Efficacy and Long-Term Safety of a Dengue Vaccine in Regions of Endemic Disease. N Engl J Med. 2015;373(13):1195-206.

9.Dans AL, Dans LF, Lansang MAD, Silvestre MAA, Guyatt GH. Controversy and debate on dengue vaccine series-paper 1: review of a licensed dengue vaccine: inappropriate subgroup analyses and selective reporting may cause harm in mass vaccination programs. J Clin Epidemiol. 2018;95:137-9.

10. Guyatt G, Oxman AD, Akl EA, Kunz R, Vist G, Brozek J, et al. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011;64(4):383-94.

11. https://bestpractice.bmj.com/info/toolkit/learn-ebm/what-is-grade/

12.Guyatt G, Vist G, Falck-Ytter Y, Kunz R, Magrini N, Schunemann H. An emerging consensus on grading recommendations? ACP J Club. 2006;144(1):A8-9.

Hosted on Acast. See acast.com/privacy for more information.

Hosted on Acast. See acast.com/privacy for more information.

Hosted on Acast. See acast.com/privacy for more information.

Det multiresistente fremtidsscenarioet ble plutselig virkelighet. Kristian Tonby forteller om sitt møte med evakuerte krigsskadde pasienter fra Ukraina, og om hvordan vi kan håndtere multiresistente mikrober.

Litteratur:

Metodebok i infeksjonsmedisin, OUS: Infeksjoner med multiresistente bakterier (metodebok.no)

Medevac: https://www.oslo-universitetssykehus.no/avdelinger/direktorens-stab/stab-medisin-helsefag-og-beredskap/medevac/

Hosted on Acast. See acast.com/privacy for more information.

Ingrid og Jørgen snakker (mest) løst og (litt) fast om parasitter og vertskap. Fra zombiesoppen i serien "The last of us", drar vi på vandring videre gjennom noen av verdens (ekte) parasitter. Bli med på parasittekspedisjon!

Referanser:

1.Backman I. “The Last of Us” Apocalypse Is Not Realistic, But Rising Threat of Fungal Pathogens Is. Yale school of medicine - webpage. 2023.

2.Del Brutto OH, Garcia HH. Taenia solium Cysticercosis--The lessons of history. J Neurol Sci. 2015;359(1-2):392-5.

3.Hughes DP, Andersen SB, Hywel-Jones NL, Himaman W, Billen J, Boomsma JJ. Behavioral mechanisms and morphological symptoms of zombie ants dying from fungal infection. BMC Ecol. 2011;11:13.

4.Kintzen W. The Caduceus Motif and The Guinea Worm. JAMA. 1968;203(3):234-.

5.Pontoppidan MB, Himaman W, Hywel-Jones NL, Boomsma JJ, Hughes DP. Graveyards on the move: the spatio-temporal distribution of dead ophiocordyceps-infected ants. PLoS One. 2009;4(3):e4835.

6.Rosania K. Tricking rats into liking cats. Lab Anim (NY). 2011;40(10):288.

7.Saevik BK, Krontveit RI, Eggen KP, Malmberg N, Thoresen SI, Prestrud KW. Toxoplasma gondii seroprevalence in pet cats in Norway and risk factors for seropositivity. J Feline Med Surg. 2015;17(12):1049-56.

8.Webster JP. Rats, cats, people and parasites: the impact of latent toxoplasmosis on behaviour. Microbes Infect. 2001;3(12):1037-45.

9.Wilcox RA, Whitham EM. The symbol of modern medicine: why one snake is more than two. Ann Intern Med. 2003;138(8):673-7

10 Save the guinea-worm-foundation: http://www.deadlysins.com/guinea-worm

11 Ophiocordyceps unilateralis - Wikipedia

Hosted on Acast. See acast.com/privacy for more information.

Norwegian:

Vi intervjuer en av verdens fremste eksperter og forskere på antimikrobiell resistens: Adam Roberts fra Liverpool School of Tropical Medicine! Episoden finnes også i engelsk versjon.

References/supplementary reading:

1.Allel K, Day L, Hamilton A, Lin L, Furuya-Kanamori L, Moore CE, et al. Global antimicrobial-resistance drivers: an ecological country-level study at the human-animal interface. Lancet Planet Health. 2023;7(4):e291-e303.

2.Roberts AP. Swab and Send: a citizen science, antibiotic discovery project. Future Sci OA. 2020;6(6):FSO477.

3. AMR Review. https://amr-review.org/

Hosted on Acast. See acast.com/privacy for more information.

In this first-ever english episode of Pestpodden, we are interviewing one of the worlds leading experts and researchers within the field of antimicrobial resistance; Adam Roberts from Liverpool School of Tropical Medicine. There is hope!

References/supplementary reading:

1.Allel K, Day L, Hamilton A, Lin L, Furuya-Kanamori L, Moore CE, et al. Global antimicrobial-resistance drivers: an ecological country-level study at the human-animal interface. Lancet Planet Health. 2023;7(4):e291-e303.

2.Roberts AP. Swab and Send: a citizen science, antibiotic discovery project. Future Sci OA. 2020;6(6):FSO477.

3. AMR Review. https://amr-review.org/

Hosted on Acast. See acast.com/privacy for more information.

Synes du også resistens er vanskelig? Fatt mot og bli med oss i Pestpodden på en reise gjennom resistensen! I anledning Antibiotikauken 2023 har vi nemlig to spesialepisoder. I del èn får du en enkel intro til antimikrobiell resistens - mens i del to intervjuer vi en av verdens fremste eksperter og forskere på feltet; Adam Roberts. Gled deg!

Referanser:

1.Barlow M, Hall BG. Phylogenetic analysis shows that the OXA beta-lactamase genes have been on plasmids for millions of years. J Mol Evol. 2002;55(3):314-21.

2.D'Costa VM, King CE, Kalan L, Morar M, Sung WW, Schwarz C, et al. Antibiotic resistance is ancient. Nature. 2011;477(7365):457-61.

3. Holmes AH, Moore LS, Sundsfjord A, Steinbakk M, Regmi S, Karkey A, et al. Understanding the mechanisms and drivers of antimicrobial resistance. Lancet. 2016;387(10014):176-87.

4.Woerther PL, Andremont A, Kantele A. Travel-acquired ESBL-producing Enterobacteriaceae: impact of colonization at individual and community level. J Travel Med. 2017;24(suppl_1):S29-s34.

5.NORM/NORM-VET 2022. Usage of Antimicrobial Agents and Occurrence of Antimicrobial Resistance in Norway. Tromsø / Oslo 2023. ISSN:1502-2307 (print) / 1890-9965 (electronic). . 2022.

7. https://atlas.ecdc.europa.eu/public/index.aspx?Dataset=27&HealthTopic=4

8.Antimicrobial Resistance C. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet. 2022;399(10325):629-55.

Hosted on Acast. See acast.com/privacy for more information.