Welcome to episode 053 of Life Sciences 360.

In this episode of Life Science 360, our host Harsh Thakkar sits down with Brian Cosgrove, Principal Scientist at Tune Therapeutics. Brian dives deep into the fascinating world of epigenetics and its role in developing therapies for complex diseases. He shares insights on how Tune Therapeutics is leveraging the power of the epigenome to create innovative treatments, particularly focusing on their work with hepatitis B and the promising potential of their tempo platform.

Chapters:

00:00 - Introduction
00:02 - Understanding Cell Differentiation and Gene Regulation
00:37 - Welcome Brian Cosgrove from Tune Therapeutics
01:15 - Brian's Transition from Duke University to Tune Therapeutics
02:03 - The Basics of Epigenetic Tuning
02:38 - How Epigenetics Determines Cell Function
03:55 - The Role of the Epigenome in Gene Expression
05:06 - The Complexity of the Human Body and Scientific Research
06:12 - Deep Dive into Hepatitis B (HBV)
06:57 - Current Treatments for Chronic Hepatitis B
08:32 - The Unmet Need in Hepatitis B Treatment
09:09 - Brian's Career Path and Decision to Join Tune Therapeutics
12:03 - Growth and Evolution of Tune Therapeutics
15:25 - Challenges and Rewards of Joining an Early-Stage Company
17:49 - Introduction to the Tempo Platform
19:04 - How Tempo Platform Works with HBV
20:32 - Epigenetic Regulation of HBV
23:20 - Future Applications of Epigenetic Tuning
24:38 - Timeline for Tune 401 Clinical Trials
26:08 - Anticipated Challenges and Solutions
27:20 - Partnering for Manufacturing and Delivery
28:32 - The Broader Field of Epigenetic Therapies
30:21 - Potential Global Impact of Epigenetic Therapies
32:12 - The Most Rewarding Part of Brian's Work
33:01 - The Personal Side of Working in Life Sciences
35:10 - Final Thoughts and Future Outlook for Tune Therapeutics
36:09 - Closing Remarks and How to Connect with Brian

Stay tuned and don't forget to subscribe for more in-depth conversations with leading scientists and innovators in the life sciences field!

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Links:

*Brian Cosgrove LinkedIn (https://www.linkedin.com/in/brian-cosgrove-171b926/)
*Tune Therapeutics LinkedIn (https://www.linkedin.com/company/tunetx/ )
*Tune Therapeutics website (https://tunetx.com/)
*Harsh Thakkar LinkedIn ( https://www.linkedin.com/in/harshvthakkar/ )
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