• Why serotonin is NOT the “happy hormone” and you may not want to increase it
• How serotonin and depression relate to stress and energy balance
• Whether SSRIs are effective for depression
• How SSRIs actually work, their impact on metabolism, and whether they’re the best treatment option for depression
• The real drivers of depression and anxiety

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-118-the-truth-about-serotonin-and-ssris-why-serotonin-is-not-the-happy-hormone

Timestamps:

0:00 – intro

0:58 – the research showing that serotonin is not the “happy hormone”

4:56 – serotonin’s role in driving the stress state that leads to depression

8:26 – the overlap between anxiety and depression and why they are both characterized by elevated serotonin levels

10:27 – the origins of the idea that serotonin is the “happy hormone” and how serotonin became a marketing tool for pharmaceutical companies

14:49 – serotonin is increased during fasting and starvation and why increasing serotonin should not be our goal

20:16 – serotonin is increased during stress, shock, and infection and leads to learned helplessness

29:04 –SSRIs use in neonates causes depression in adulthood

31:35 – the serotonergic system as an adaptive stress response to a lack of energy

39:09 – serotonin’s role in energy redistribution under stress

43:15 – how SSRIs inhibit mitochondrial respiration, glucose metabolism, and energy production in the brain and liver

47:13 – how SSRIs can reduce symptoms and how the brain responds to SSRIs

52:42 – the true drivers of depression and anxiety

1:01:30 – how serotonin relates to stress hormones, including cortisol, and energy balance

• Concerns surrounding fructose malabsorption and whether fructose is really a FODMAP
• Whether you need to be concerned about excess fructose in foods
• Whether you should avoid sugar and supplement with fish oil for brain inflammation
• Diet and supplement strategies for brain injuries
• The impacts of drinking alcohol from the Bioenergetic view

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-117-fructose-malabsorption-protecting-against-alcohol-and-brain-injuries-and-inflammation-q-and-a

Timestamps:

0:00 – intro

1:15 – how fructose gets absorbed in the small intestine

4:24 – the optimal fructose to glucose ratio and how to tell if you have fructose malabsorption

8:41 – the details of how glucose helps with fructose absorption

12:04 – which foods have a high fructose to glucose ratio

16:24 – issues with FODMAP categorization and whether fructose is really a FODMAP

21:23 – listening to your body and understanding individual context vs following rigid “food rules”

27:39 – anti-inflammatory diets and whether we should avoid sugar and supplement with fish oil to reduce brain inflammation

32:06 – dietary and supplement strategies to promote an anti-inflammatory state in the brain

39:15 – the effectiveness of red-light therapy, methylene blue, progesterone, exogenous ketones, and polyphenols in treating brain injuries

44:31 – why we don’t want to prioritize omega 3s in the diet and whether eating fish is any better than fish oil supplementation

47:21 – reducing inflammation with the use of aspirin

47:53 – the main concerns with drinking alcohol: intestinal permeability, endotoxin production, and liver health

52:32 – stress-relieving supplement alternatives to alcohol and the effects of alcohol on vitamins and minerals

54:37 – strategies to mitigate the effects of alcohol in the short-term

58:14 – whether it makes sense to drink alcohol, alcohol use as a coping mechanism, and the impact of culture

1:00:07 – more strategies for mitigating the effects of alcohol in the short and long term

• The validity of the counterarguments against the Lipid Energy Model
• Whether the Lipid Energy Model means that high LDL does not increase cardiovascular disease risk
• How thyroid and metabolism relate to high LDL on a low-carb diet
• What the Lean Mass Hyper-Responder phenotype means in terms of metabolic health
• Whether low-carb diets are ideal for cardiovascular disease health and health in general

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-116-the-truth-about-ldl-and-heart-disease-lmhr-and-the-lipid-energy-model/

Timestamps:

0:00 – intro

1:17 – the primary counterarguments against the Lipid Energy Model

4:15 – BMI, not saturated fat, correlates with the LMHR phenotype

8:15 – eating carbs dramatically lowers cholesterol in LMHR

11:14 – whether Oreos are more effective at lowering cholesterol than statins

17:30 – high cholesterol levels in the LMHR phenotype are not due to excess saturated fat intake or cholesterol production

19:25 – prominent cardiologists and researchers dismissing the lipid energy model due to dogmatism interferes with progress in science and medicine

24:40 – Dr. Shawn Baker’s carbohydrate experiment and contextual considerations when reintroducing carbs into the diet

28:46 – further support for the lipid energy model and the relationship with thyroid function

33:32 – the difference between saturated, monounsaturated, and polyunsaturated fats in relation to lipid profiles

34:40 – whether LDL cholesterol and ApoB cause heart disease and plaque formation

42:18 – how the Lipid Energy Model helps uncover the underlying cause of heart disease

45:15 – LDL levels as a marker of metabolic health rather than a cause of cardiovascular disease and why we may not always want to lower LDL

55:02 – evidence suggesting that LDL does not drive cardiovascular disease

1:05:43 – the difference between high LDL due to metabolic dysfunction and high LDL due to a low-carb diet

1:09:58 – lipid values don’t tell us the whole picture: the Kitavans

1:16:54 – why decreases in insulin, glucose, and HbA1C as well as increased lipolysis and fat oxidation on a low-carb diet is not necessarily a sign of improvement

1:22:57 – increased lipolysis on low-carb diets does not lead to body-fat loss

1:24:25 – whether the Lipid Energy Model proves that low-carb diets are optimal for health