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In this episode of Journal Club, Ben and Daphna discuss several recent neonatal studies. They begin with a paper from Pediatrics examining variability in care practices for extremely early deliveries (22-24 weeks gestation), highlighting changes over time and persistent differences between centers. They also review a commentary on important questions raised by these variations in care.

The hosts then analyze a study on the use of inhaled nitric oxide in preterm infants, discussing its effectiveness, costs, and potential overuse. They cover a paper on monocyte count trends as a potential diagnostic tool for necrotizing enterocolitis.

A special segment features Dr. Jane Stremming discussing a New England Journal of Medicine study on nutritional support for moderate to late preterm infants. The hosts also touch on new treatments for hemolytic disease of the fetus and newborn, and surfactant use in infants who develop bronchopulmonary dysplasia.

The episode concludes with an ethical case study about a father's unexpected request to withdraw care for his preterm infant, emphasizing the importance of understanding families' perspectives in complex medical decisions.

As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Beyond the Question: Reexamining a Parent's Unusual Request.

Callahan KP, Narva A, Stoller JZ, Fiester A.Pediatrics. 2024 Aug 1;154(2):e2023064954. doi: 10.1542/peds.2023-064954.PMID: 39040023

As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Surfactant treatment at birth in a contemporary cohort of preterm infants with bronchopulmonary dysplasia.

Mueller C, Shepherd EG, Kielt MJ, Conroy S, Jensen EA, Bamat NA, Panitch H, Levin J, Guaman Cuevas M, Truog W, Abman SH, Nelin LD; BPD Collaborative.J Perinatol. 2024 Jul 17. doi: 10.1038/s41372-024-02061-8. Online ahead of print.PMID: 39020028

As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Retrospective study of preterm infants exposed to inhaled nitric oxide in Kaiser Permanente Southern California: morbidity, mortality and follow-up.

Bhatt DR, Braun D, Dizon RA, Shi JM, Weerasinghe S, Sabio A, Reddy S, Lee HC, Ramanathan R, Lakshminrusimha S.J Perinatol. 2024 Jul 18. doi: 10.1038/s41372-024-02051-w. Online ahead of print.PMID: 39025953

As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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The Value of Parental Judgment in the Ethical Gray Zone of Periviability: Words Matter.

Drago MJ, Mercurio MR.Pediatrics. 2024 Aug 7:e2024065986. doi: 10.1542/peds.2024-065986. Online ahead of print.PMID: 39108223 No abstract available.

As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Four Important Questions About Between-Hospital Differences in Care at <25 Weeks' Gestation.

Rysavy MA, Battarbee AN, Gibson KS.Pediatrics. 2024 Aug 12:e2024066182. doi: 10.1542/peds.2024-066182. Online ahead of print.PMID: 39129508 No abstract available.

As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Variability of Care Practices for Extremely Early Deliveries.

LoRe D, Groden CM, Schuh AR, Holmes C, Ostilla L, Vogel MM, Murray PD, Yamasato K, Tonismae T, Anani UE, Henner N, Famuyide M, Leuthner SR, Laventhal N, Andrews BL, Tucker Edmonds BM, Brennan KG, Feltman DM; INVESTIGATING NEONATAL DECISIONS FOR EXTREMELY EARLY DELIVERIES (INDEED) STUDY GROUP.Pediatrics. 2024 Aug 12:e2023065521. doi: 10.1542/peds.2023-065521.

As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Effects of a live versus heat-inactivated probiotic Bifidobacterium spp in preterm infants: a randomised clinical trial.

Athalye-Jape G, Esvaran M, Patole S, Nathan EA, Doherty DA, Sim E, Chandrasekaran L, Kok C, Schuster S, Conway P.Arch Dis Child Fetal Neonatal Ed. 2024 Aug 17:fetalneonatal-2023-326667. doi: 10.1136/archdischild-2023-326667.

As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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