It’s Episode 13 of The Nephron Segment and it's time for NephMadness! Join us as we chat with transplant nephrologist Dr. Roslyn Mannon & transplant hepatologist Dr. Elizabeth Aby and discuss all things dual-organ transplantation: liver-kidney, pancreas-kidney, kidney after liver, kidney after pancreas, or even kidney alone?! Listen to the end to hear everyone's picks for NephMadness 2024.

And to be clear, Dr. Mannon supported the Kansas City Chiefs before their Super Bowl 58 win.

Submit your NephMadness brackets here (just like March Madness!) by 3/31. Maximize your changes by submitting 2 brackets per email address.

Nephrons: Matthew Sparks, Samira Farouk

Guests: Roslyn Mannon, Lizzie Aby

In Episode 12, Dr. William Cushman, co-investigator of the 2015 SPRINT (Systolic Blood Pressure Intervention) Trial, joins us for a discussion all about hypertension trials, their long history, and what's ahead for research in this space. Too young to remember SPRINT or looking for a "CliffsNotes" of HTN trials? This episode's for you!

Here's a Renal Fellow Network post from 2017 with a link to a cheat sheet of hypertension clinical trial.

Nephrons: Matthew Sparks, Samira Farouk

Guests: William Cushman, Medical Director & Professor, Department of Preventive Medicine, University of Tennessee

Links from the Show:

00:41: Systolic Blood Pressure Intervention Trial (2015)

02:17: VA Cooperative Study (1967)

05:13: ACCORD Study (2010)

06:30: SPRINT MIND (2019)

08:40: Framingham Heart Study (Started 1948)

11:27: Attended vs. unattended blood pressure – learnings beyond SPRINT (2021)

14:03: Systolic Hypertension in the Elderly Program Study (1989)

14:05: Hypertension Detection & Follow Up Program (1979)

15:32: JNC 8 Guidelines (2014)

16:01 AHA/ACC Guidelines (2017)

17:54: Syst-Eur (Treatment of HTN in Patients > 60 y, 1998)

17:54: HYVET (Treatment of HTN in Patients > 80 y, 2008)

18:01: Syst-China (2000)

22:18: AAFP HTN Guidelines (2022)

22:40: KDIGO HTN Guidelines (2021)

25:37: ALLHAT Study (2002)

32:22: Secondary Prevention of Small Subcortical Strokes Trial (SPS3, 2013)

In Episode 11, guests Jordy Cohen & Samir Parikh (and members of the American Society of Nephrology Kidney Week Education Committee) join us for a discussion about Kidney Week 2023 and their careers as physician-scientists. They discuss their journeys to their current careers, what inspired them to pursue nephrology ("beautiful ribbons of anti-GBM"), and share their advice for trainees. 

For more on Kidney Week 2023, here's a Doximity op-ed.

Nephrons: Matthew Sparks, Samira Farouk

Guests: Jordy Cohen, Samir Parikh

Links from the Show:

02:03: PLA2R & Membranous Nephropathy (2009)

04:03: Sflt-1

05:05: FLOW & GLP-1

05:55: ACC HTN Guidelines (2017)

09:33: Bill McKibben Plenary: Too Hot & Inhuman Temperatures

10:45: Climate change & heat stress nephropathy

11:00: Ardem Patapoutian Plenary: How Do You Feel? The Molecules that Sense Touch

13:03: Obesity & RAS Activation (Mice)