Showing titles in History & Commentary

For centuries, the human heart seemed beyond our understanding: an inscrutable shuddering mass that was somehow the driver of emotion and the seat of the soul. As cardiologist and best-selling author Sandeep Jauhar tells in The Heart, it was only recently that we demolished age-old taboos and devised the transformative procedures that changed the way we live. Deftly alternating between historical episodes and his own work, Jauhar tells the colorful and little known story of the doctors who risked their careers and the patients who risked their lives to know and heal our most vital organ.

We know it simply as "the pill", yet its genesis was anything but simple. Jonathan Eig's masterful narrative revolves around four principal characters: the fiery feminist Margaret Sanger, who was a champion of birth control in her campaign for the rights of women but neglected her own children in pursuit of free love; the beautiful Katharine McCormick, who owed her fortune to her wealthy husband, the son of the founder of International Harvester and a schizophrenic.

Following the trail of an unexpected family connection, acclaimed journalist Pam Fessler has unearthed the lost world of the patients, nurses, doctors, and researchers at Carville who struggled for over a century to eradicate Hansen's disease, the modern name for leprosy. Amid widespread public anxiety about foreign contamination and contagion, patients were deprived of basic rights - denied the right to vote, restricted from leaving Carville, and often forbidden from contact with their own parents or children.

Written by an author with plenty of experience holding a scalpel, Dr. David Schneider's in-depth biography is an encompassing history of the practice that has leapt forward over the centuries from the dangerous guesswork of ancient Greek physicians through the world-changing implant revolution of the 20th century.

Intensive care units and mechanical ventilation are the crucial foundation of modern medical care: without them, the appalling death toll of the COVID-19 pandemic would be even higher. In The Autumn Ghost, Dr. Hannah Wunsch traces the origins of these two innovations back to a polio epidemic in the autumn of 1952. Drawing together testimony from doctors, nurses, medical students, and patients, Wunsch relates a gripping tale of an epidemic that changed the world.

Mark Gober dives into fundamental beliefs about health and disease. These beliefs are so fundamental, in fact, that most of us probably haven’t thought to question them. For example, do bacteria cause disease, or are they part of the body’s cleanup crew that appears at the scene of an underlying toxicity or injury? Do researchers follow the scientific method when they claim to isolate viruses and show that they cause disease in their hosts? In addition to exploring these essential questions, Gober goes a layer deeper by examining the nature of consciousness.

Over the past 70 years, the Diagnostic and Statistical Manual of Mental Disorders, or DSM, has evolved from a virtually unknown and little-used pamphlet to an imposing and comprehensive compendium of mental disorder. Its nearly 300 conditions have become the touchstones for the diagnoses that patients receive, students are taught, researchers study, insurers reimburse, and drug companies promote.

In 1918, a world war raged, and a lethal strain of influenza circled the globe. In the midst of all this death, a bizarre disease appeared in Europe. Eventually known as encephalitis lethargica, or sleeping sickness, it spread worldwide, leaving millions dead or locked in institutions. Then, in 1927, it disappeared as suddenly as it had arrived. Asleep, set in 1920s and '30s New York, follows a group of neurologists through hospitals and asylums as they try to solve this epidemic and treat its victims - who learned the worst fate was not dying of it, but surviving it.

In the middle of the second century AD, Rome was at its prosperous and powerful apex. The emperor Marcus Aurelius reigned over a vast territory that stretched from Britain to Egypt. The Roman-made peace, or Pax Romana, seemed to be permanent. Then, apparently out of nowhere, a sudden sickness struck the legions and laid waste to cities, including Rome itself. This fast-spreading disease, known now as the Antonine plague, may have been history’s first pandemic. Soon after its arrival, the Empire began its downward trajectory toward decline and fall.

After his father died, James L. Nolan, Jr., took possession of a box of private family materials. To his surprise, the small secret archive contained a treasure trove of information about his grandfather's role as a doctor in the Manhattan Project. Dr. Nolan, it turned out, had been a significant figure.

In 1866, 12 men and women and one small child were forced aboard a leaky schooner and cast away to a natural prison on the Hawaiian island of Molokai. Two weeks later, a dozen others were exiled, and then 40 more, and then 100 more. Tracked by bounty hunters and torn screaming from their families, the luckless were loaded into shipboard cattle stalls and abandoned in a lawless place where brutality held sway. Many did not have leprosy, and most of those who did were not contagious.

In this astonishing and startling book, award-winning science and history writer Robert Whitaker investigates a medical mystery: Why has the number of disabled mentally ill in the United States tripled over the past two decades? Every day, 1,100 adults and children are added to the government disability rolls because they have become newly disabled by mental illness, with this epidemic spreading most rapidly among our nations children. What is going on?

The Nobel laureate Otto Warburg was widely regarded in his day as one of the most important biochemists of the 20th century, a man whose research was integral to humanity’s understanding of cancer. He was also among the most despised figures in Nazi Germany. As a Jewish homosexual living openly with his male partner, Warburg represented all that the Third Reich abhorred. Yet Hitler and his top advisors dreaded cancer, and protected Warburg in the hope that he could cure it.

For 200 years, a noble Venetian family has suffered from an inherited disease that strikes their members in middle age, stealing their sleep, eating holes in their brains, and ending their lives in a matter of months. In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. What these strange conditions share is their cause: prions.

The struggle to perform well is universal: each one of us faces fatigue, limited resources, and imperfect abilities in whatever we do. But nowhere is this drive to do better more important than in medicine, where lives are on the line with every decision. In this book, Atul Gawande explores how doctors strive to close the gap between best intentions and best performance in the face of obstacles that sometimes seem insurmountable.

At the height of World War I, history’s most lethal influenza virus erupted in an army camp in Kansas, moved east with American troops, then exploded, killing as many as 100 million people worldwide. It killed more people in twenty-four months than AIDS killed in twenty-four years, more in a year than the Black Death killed in a century. But this was not the Middle Ages, and 1918 marked the first collision of science and epidemic disease.

On June 25, 1973, a seven-year-old girl went missing from the Montana campground where her family was vacationing. Somebody had slit open the back of their tent and snatched her from under their noses. None of them saw or heard anything. Susie Jaeger had vanished into thin air, plucked by a shadow. As days stretched into weeks, and weeks into months, Special Agent Pete Dunbar attended a workshop at FBI Headquarters in Quantico, Virgina, led by two agents who had hatched a radical new idea: What if criminals left a psychological trail that would lead us to them?

Early studies of the human brain used a simple method: Wait for misfortune to strike - strokes, seizures, infectious diseases, horrendous accidents - and see how victims coped. In many cases their survival was miraculous, if puzzling. Observers were amazed by the transformations that took place when different parts of the brain were destroyed, altering victims' personalities. With the lucid, masterful explanations and razor-sharp wit his fans have come to expect, Kean explores the brain's secret passageways.

What won't we try in our quest for perfect health, beauty, and the fountain of youth? Well, just imagine a time when doctors prescribed morphine for crying infants. When liquefied gold was touted as immortality in a glass. And when strychnine - yes, that strychnine, the one used in rat poison - was dosed like Viagra. Looking back with fascination, horror, and not a little dash of dark, knowing humor, Quackery recounts the lively, at times unbelievable, history of medical misfires and malpractices.

In the early 1960s, Dr. Frances Oldham Kelsey of the U.S. Food and Drug Administration became one of the most celebrated women in America when she prevented a deadly sedative from entering the U.S. market. A Canadian-born pharmacologist and physician, Kelsey saved countless Americans from the devastating side effects of thalidomide, routinely given to pregnant women to prevent morning sickness. As the FDA medical officer charged with reviewing Merrell Pharmaceutical’s application for approval, Kelsey was unconvinced that there was sufficient evidence of the drug’s efficacy and safety.