-
Lifespan
- Why We Age - and Why We Don't Have To
- Narrado por: David A. Sinclair PhD
- Duración: 11 h y 55 m
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Resumen del Editor
Audio bonus! Includes exclusive conversations with the authors!
From an acclaimed Harvard professor and one of Time’s most influential people, this paradigm-shifting audiobook shows how almost everything we think we know about aging is wrong, offers a front-row seat to the amazing global effort to slow, stop, and reverse aging, and calls listeners to consider a future where aging can be treated.
For decades, experts have believed that we are at the mercy of our genes and that natural damage to our genes - the kind that inevitably happens as we get older - makes us become sick and grow old.
But what if everything you think you know about aging is wrong? What if aging is a disease - and that disease is treatable?
In Lifespan, one of the world’s foremost experts on aging and genetics reveals a groundbreaking new theory that will forever change the way we think about why we age and what we can do about it. Aging isn’t immutable; we can have far more control over it than we realize. This eye-opening and provocative work takes us to the front lines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs - many from Dr. David Sinclair’s own lab - that demonstrate how we can slow down, or even reverse, the genetic clock. The key is activating newly discovered vitality genes - the decedents of an ancient survival circuit that is both the cause of aging and the key to reversing it. Dr. Sinclair shares the emerging technologies and simple lifestyle changes - such as intermittent fasting, cold exposure, and exercising with the right intensity - that have been shown to help lead to longer lives.
Lifespan provides a road map for taking charge of our own health destiny and a bold new vision for the future when humankind is able to live to be 100 years young.
PLEASE NOTE: When you purchase this title, the accompanying PDF will be available in your Audible Library along with the audio.
Featured Article: The 20 Best Fitness Audiobooks for Becoming Your Healthiest Self
Fitness audiobooks have the power to inspire and motivate us to change ourselves, whether through tough love or peeks into the amazing transformations of others. As one of the most consistently popular audiobook genres, there are countless selections with a plethora of information about the road to better health. Here, discover titles that communicate truths about health and fitness by examining the nutrition industry and human motivations.
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Very enlightening and information well supported
- De James en 05-03-15
De: Martin J. Blaser
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The Cancer Chronicles
- Unlocking Medicine's Deepest Mystery
- De: George Johnson
- Narrado por: Arthur Morey
- Duración: 8 h y 19 m
- Versión completa
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When the woman he loved was diagnosed with a metastatic cancer, science writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is a revolution under way - an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease.
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A quick read - hard to put down
- De Digital Dilema en 09-06-13
De: George Johnson
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Ravenous
- Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection
- De: Sam Apple
- Narrado por: Mark Bramhall
- Duración: 12 h y 58 m
- Versión completa
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The Nobel laureate Otto Warburg was widely regarded in his day as one of the most important biochemists of the 20th century, a man whose research was integral to humanity’s understanding of cancer. He was also among the most despised figures in Nazi Germany. As a Jewish homosexual living openly with his male partner, Warburg represented all that the Third Reich abhorred. Yet Hitler and his top advisors dreaded cancer, and protected Warburg in the hope that he could cure it.
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Highly recommended, a must read.
- De Joerg en 06-10-21
De: Sam Apple
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Denialism
- How Irrational Thinking Hinders Scientific Progress, Harms the Planet, and Threatens Our Lives
- De: Michael Specter
- Narrado por: Richard Poe
- Duración: 8 h y 33 m
- Versión completa
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New Yorker staff writer Michael Specter has twice won the Global Health Council’s Excellence in Media Award, as well as the Science Journalism Award from the American Association for the Advancement of Science. In Denialism, he fervently argues that people are turning away from new technologies and engaging in a kind of magical thinking that is hindering scientific progress.
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A compelling read
- De S en 05-17-11
De: Michael Specter
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The Language of Life
- DNA and the Revolution in Personalized Medicine
- De: Francis S. Collins
- Narrado por: Greg Itzin
- Duración: 10 h y 45 m
- Versión completa
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Historia
A scientific and medical revolution has crept up on us, based on study after study, from hundreds of laboratories around the world. It is no longer just a theoretical shift: every one of us will be touched by it, and many of us already have been. The meaning of disease, our understanding of the human body, and crucial decisions about what we all need to know and what choices we make about our health are at stake. Welcome to the new world of personalized medicine.
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The future of medicine
- De Ronald E en 04-12-10
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An Epidemic of Absence
- A New Way of Understanding Allergies and Autoimmune Diseases
- De: Moises Velasquez-Manoff
- Narrado por: Chris Sorensen
- Duración: 17 h y 6 m
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An Epidemic of Absence asks what will happen in developing countries, which, as they become more affluent, have already seen an uptick in allergic disease: Will India end up more allergic than Europe? Velasquez-Manoff also details a controversial underground movement that has coalesced around the treatment of immune-mediated disorders with parasites. Against much of his better judgment, he joins these do-it-yourselfers and reports his surprising results.
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The point of view from a Veterinarian immunologist
- De rtgymnast en 11-03-17
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Pandora's Seed
- The Unforeseen Cost of Civilization
- De: Spencer Wells
- Narrado por: Spencer Wells
- Duración: 6 h y 40 m
- Versión completa
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Historia
This new book by Spencer Wells, the internationally known geneticist, anthropologist, author, and director of the Genographic Project, focuses on the seminal event in human history: mankind's decision to become farmers rather than hunter-gatherers.
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Short and unfocused, but often quite interesting.
- De Alan en 06-23-10
De: Spencer Wells
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Plague of Corruption
- Restoring Faith in the Promise of Science
- De: Dr. Judy Mikovits, Kent Heckenlively, Robert F. Kennedy Jr.
- Narrado por: Mariel Hemingway
- Duración: 10 h y 10 m
- Versión completa
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Dr. Judy Mikovits is a modern-day Rosalind Franklin, a brilliant researcher shaking up the old boys' club of science with her groundbreaking discoveries. And like many women who have trespassed into the world of men, she uncovered decades-old secrets that many would prefer to stay buried.
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If only most of the public knew these facts
- De David Getoff, CCN en 06-18-20
De: Dr. Judy Mikovits, y otros
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Ten Drugs
- How Plants, Powders, and Pills Have Shaped the History of Medicine
- De: Thomas Hager
- Narrado por: Angelo Di Loreto
- Duración: 8 h y 39 m
- Versión completa
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Beginning with opium, the “joy plant,” which has been used for 10,000 years, Thomas Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.
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Engrossing to physicians & lay persons alike
- De C. White en 03-08-19
De: Thomas Hager
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The Truth About Cancer
- De: Ty M. Bollinger
- Narrado por: Ty M. Bollinger
- Duración: 9 h y 11 m
- Versión completa
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Historia
One out of three women alive today, and one out of two men, will face a cancer diagnosis, according to the World Health Organization. Ty Bollinger takes this personally: in the course of a decade, he says, "I lost my entire family to cancer. I don't believe I had to lose them." The Truth about Cancer has been written for one simple reason: to share the knowledge we need to protect ourselves, treat ourselves, and in some cases save our lives or the lives of those we love.
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save a life with this valuable information.
- De edwin matias en 12-30-16
De: Ty M. Bollinger
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The Story of the Human Body
- Evolution, Health, and Disease
- De: Daniel Lieberman
- Narrado por: Sean Runnette
- Duración: 14 h y 54 m
- Versión completa
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General
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Historia
In this landmark book of popular science, Daniel E. Lieberman - chair of the department of human evolutionary biology at Harvard University and a leader in the field - gives us a lucid and engaging account of how the human body evolved over millions of years, even as it shows how the increasing disparity between the jumble of adaptations in our Stone Age bodies and advancements in the modern world is occasioning this paradox: greater longevity but increased chronic disease.
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Could Have Been Good, but...
- De Trebla en 04-08-18
De: Daniel Lieberman
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p53: The Gene That Cracked the Cancer Code
- De: Sue Armstrong
- Narrado por: Elizabeth Jasicki
- Duración: 9 h y 55 m
- Versión completa
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p53: The Gene That Cracked the Cancer Code reveals the tale of the search for this gene, as well as the excitement of the hunt for new cures - the hype, the lost opportunities, the blind alleys, and the thrilling breakthroughs. As the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms starts to take off at last, p53 is still at the forefront of the game. This is a timely tale of scientific discovery and advances in our understanding of a disease that still affects more than one in three of us at some point in our lives.
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Excellent story! Unfortunate narration at start
- De Adriana en 12-25-14
De: Sue Armstrong
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The Compatibility Gene
- How Our Bodies Fight Disease, Attract Others, and Define Our Selves
- De: Daniel M. Davis
- Narrado por: Christopher Grove
- Duración: 7 h y 48 m
- Versión completa
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Most of the 25,000 genes we possess are the same for all of us. Compatibility genes are those that vary most from person to person and give each of us a unique molecular signature. These genes determine both the extent to which we are susceptible to a vast range of illnesses and the different ways each of us fights disease.
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If interested in medicine, got to read
- De Howard Sterling en 06-29-16
De: Daniel M. Davis
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Sicker, Fatter, Poorer
- The Urgent Threat of Hormone-Disrupting Chemicals on Our Health and Future . . . and What We Can Do About It
- De: Leonardo Trasande MD MPP
- Narrado por: Leonardo Trasande MD MPP
- Duración: 6 h y 44 m
- Versión completa
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Historia
Lurking in our homes, hiding in our offices, and polluting the air we breathe is something sinister. Something we’ve turned a blind eye to for far too long. Dr. Leonardo Trasande, a pediatrician, professor, and world-renowned researcher, tells the story of how our everyday surroundings are making us sicker, fatter, and poorer. Through a blend of narrative, scientific detective work, and concrete information about the connections between chemicals and disease, he reveals what we can do to protect ourselves and our families in the short-term, and how we can help bring the change we deserve.
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The Must Read Book of 2019 is here early on Audio!
- De Ryan S en 12-21-18
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Editing Humanity
- The CRISPR Revolution and the New Era of Genome Editing
- De: Kevin Davies
- Narrado por: Kevin Davies
- Duración: 16 h y 17 m
- Versión completa
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Engrossing and captivating, Editing Humanity takes listeners inside the fascinating world of a new gene editing technology called CRISPR, a high-powered genetic toolkit that enables scientists to not only engineer but to edit the DNA of any organism down to the individual building blocks of the genetic code. Davies introduces listeners to arguably the most profound scientific breakthrough of our time. He tracks the scientists on the front lines of its research to the patients whose powerful stories bring the narrative movingly to human scale.
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Excellent content, solid execution
- De Samuel Finlayson en 01-25-21
De: Kevin Davies
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Designed for non-scientists, Six Easy Pieces is an unparalleled introduction to the world of physics by one of the greatest teachers of all time.
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When Dr. Michael Greger, founder of NutritionFacts.org, dove into the top peer-reviewed anti-aging medical research, he realized that diet could regulate every one of the most promising strategies for combating the effects of aging. We don’t need Big Pharma to keep us feeling young—we already have the tools. In How Not to Age, the internationally renowned physician and nutritionist breaks down the science of aging and chronic illness and explains how to help avoid the diseases most commonly encountered in our journeys through life.
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Where is the "accompanying pdf"
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Did you know conservatives have more orgasms?
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IMPECABLE Y NECESARIO
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How Not to Die
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The vast majority of premature deaths can be prevented through simple changes in diet and lifestyle. In How Not to Die, Dr. Michael Greger, the internationally-renowned nutrition expert, physician, and founder of NutritionFacts.org, examines the fifteen top causes of premature death in America-heart disease, various cancers, diabetes, Parkinson's, high blood pressure, and more-and explains how nutritional and lifestyle interventions can sometimes trump prescription pills and other pharmaceutical and surgical approaches, freeing us to live healthier lives.
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A stunningly important book
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Have you wondered why some 60-year-olds look and feel like 40-year-olds and why some 40-year-olds look and feel like 60-year-olds? While many factors contribute to aging and illness, Dr. Elizabeth Blackburn discovered a biological indicator called telomerase, the enzyme that replenishes telomeres, which protect our genetic heritage. Dr. Blackburn and Dr. Elissa Epel's research shows that the length and health of one's telomeres are a biological underpinning of the long-hypothesized mind-body connection.
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Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.
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In to the abyss we ascend, a scary future
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Sleep is one of the most important but least understood aspects of our life, wellness, and longevity. Until very recently, science had no answer to the question of why we sleep, or what good it served, or why we suffer such devastating health consequences when we don't sleep. Compared to the other basic drives in life - eating, drinking, and reproducing - the purpose of sleep remained elusive.
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I recommend this to EVERYONE
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How do some people avoid the slowing down, deteriorating, and weakening that plagues many of their peers decades earlier? Are they just lucky? Or do they know something the rest of us don’t? Is it possible to grow older without getting sicker? What if you could look and feel 50 through your 80s and 90s? Founder of the Institute for Aging Research at the Albert Einstein College of Medicine and one of the leading pioneers of longevity research, Dr. Nir Barzilai’s life’s work is tackling the challenges of aging to delay and prevent the onset of all age-related diseases.
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Hang on, help is coming!
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The Longevity Code
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Medical doctor and researcher Dr. Kris Verburgh is quickly emerging as one of the world's leading research authorities on the science of aging. The Longevity Code is his authoritative guide on why and how we age and on the four most crucial areas we have control over in order to slow down - and even reverse - the aging process. We learn why some animal species hardly age at all while others age and die very quickly and about the mechanisms at work that slowly but definitely cause our bodies to age, making us susceptible to heart attack, stroke, cancer, pneumonia, and dementia.
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Worth the listen
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The Plant Paradox
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- De: Steven R. Gundry MD
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Most of us have heard of gluten - a protein found in wheat that causes widespread inflammation in the body. Americans spend billions of dollars on gluten-free diets in an effort to protect their health. But what if we’ve been missing the root of the problem? In The Plant Paradox, renowned cardiologist Dr. Steven Gundry reveals that gluten is just one variety of a common, and highly toxic, plant-based protein called lectin.
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The proliferation of fabricated “facts”
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Ageless
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- De: Andrew Steele
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Aging - not cancer, not heart disease - is the underlying cause of most human death and suffering. The same cascade of biological changes that renders us wrinkled and gray also opens the door to dementia and disease. We work furiously to conquer each individual disease, but we never think to ask: Is aging itself necessary? Nature tells us it is not: There are tortoises and salamanders who are spry into old age and whose risk of dying is the same no matter how old they are.
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General overview of aging and aging research
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Breath
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- De: James Nestor
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There is nothing more essential to our health and well-being than breathing. Yet, as a species, humans have lost the ability to breathe correctly, with grave consequences. Journalist James Nestor travels the world to figure out what went wrong and how to fix it. The answers aren’t found in pulmonology labs, as we might expect, but in the muddy digs of ancient burial sites, secret Soviet facilities, New Jersey choir schools, and the smoggy streets of São Paulo. Nestor tracks down men and women exploring the hidden science behind ancient breathing practices.
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Does NOT coincide with Book text
- De FamAzz en 07-13-20
De: James Nestor
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The Diet Myth
- Why the Secret to Health and Weight Loss Is Already in Your Gut
- De: Tim Spector
- Narrado por: Gildart Jackson
- Duración: 12 h y 45 m
- Versión completa
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General
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Historia
What should we eat? It's a simple and fundamental question that still bewilders us despite a seemingly infinite amount of available information on which foods are best for our bodies. Scientists, dieticians, and even governments regularly publish research on the dangers of too much fat and sugar as well as on the benefits of exercise, and yet the global obesity crisis is only worsening. Most diet plans prove to be only short-term solutions, and few strategies work for everyone.
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Do not waste your credit
- De Judy en 01-22-16
De: Tim Spector
Lo que los oyentes dicen sobre Lifespan
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- S.Warrick
- 11-08-19
Great research with unneed opinions not related.
i really liked the information and working to apply applications where i can.
the research was very informative. As long as he wrote information he researching it was great, but near the end he dove off into politics and other liberal
chatter is where i was disappoint. i dont need your opinion or areas you dont research included. Stick to the research, leave the liberal BS out of future books.
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esto le resultó útil a 2 personas
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- Dane Maralason
- 09-18-21
A+ on the Science. D on the Pontificating
The science segments were fantastic! Even when they were over my head, they were still great to hear. The author does a great job reading his work. The first 1/3 of this had me locked in. I couldn't stop listening. Then came the pontificating, the social engineering, the critique of everything from climate change, to plastics. The only subject I can't recall hearing an opinion on was abortion. While the author returned to science enough to keep me listening I couldn't help but gag when he would link the end of aging with rising ocean levels that I still have yet to see in San Francisco. In over 40 years, Fisherman's Wharf hasn't sunk. Except for political excursions, I found the book to be excellent.
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- Patty Dailey
- 10-20-19
Hope for the journey
I'm a 59 year old female. Middle class. Normal wear and tear and no diseases to speak of. I eat really clean; mostly whole foods, fewer carbs, much less sugar. I take care of myself pretty well, seeking traditional and holistic therapies to enhance my body, mind and spirit. No prescribed medications. I exercise.
The "normal wear and tear", however.....
I've thought often enough to myself over the past 5 years, as my knees have given way and my energy has waned and arthritis in my hands and fingers and feet have reared up, that surely it isn't downhill from this point. I get to look forward to greater pain and impeded mobility before knee replacements and recovery and if I'm super lucky, the same for my hips. I will move less and less and with less vigor. I will seek reasons why I cannot engage and "play". With a modest lifespan of 80+ then there are 20+ years left to feel kind of crappy. I rise to occasions but the joy in movement and feeling "alive" are diminished. It makes me sad.
My husband and I both have spoken a goal of living to 100. We have a wonderful family and grandchildren and we have personal goals for experiences and travel. But I can see how my current trajectory will undermine these goals.
Dr. Mark Hyman's podcast introduced me to biologist David Sinclair. I have just completed listening (and taking notes) to the Audible book. Mr. Sinclair has a wonderful ability to make this science of aging perfectly accessible and his stories weave it all together cohesively. I was most struck by the testimony of his father, however.
I take heart that this research is being done and is coming soon to a pharmacy near me. In the meantime, however, I have just started taking NR. I plan to incorporate other suggestions from his research and personal protocols as I am able. I look forward to noting any differences that may come my way, and bring me hope.
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- Adam Karr
- 10-01-19
Bravo!
I appreciate the time Sinclair has taken out of his busy life to get this information out into the world. I also appreciate the forward thinking, and the sensible discussions he's brought forth. I think this book should give you the biggest incentive to take care of yourself. I'm 26, and one of the leaders of the Dept. of Genetics at Harvard Medical School thinks that I (in general) have a great chance to live until I'm 120. I literally quit smoking after I read this, and my wife is working on it. We're two people. I cannot imagine the number of lives this knowledge will change. I am grateful to live in this age. In this age of information, it is important to gather your knowledge from revered sources like David Sinclair PhD!
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- G B.
- 11-10-19
a brave tale
This book has consumed me the past 2 weeks or so and I've never finished one so fast while listening at normal speed. Reframing aging as a disease is not an easy sell, and even brave if you're an academic wishing to keep a career and funding. The way the public has framed growing old for themselves at present is just a coping mechanism for what they think is inevitable. On the other side, critical people might question the kind of enlightenment thinking that with enough technology we can solve everything.
Sinclair questions himself and his work like a good scientist does. But he is also an advocate for longer but more importantly healthier and vital lives. Citing cases from his personal life and family members (grandmother, father, mother, brother, son and more) who have aged or have rejuvenated, his quest for curing the disease of aging becomes very personal and can be sincerely felt as he tells about his mother dying of lung cancer.
He does a good job of explaining how medicine has succeeded at prolonging life but not necessarily prolonging vitality. And after explaining his research (mostly on mice and yeast), the workings of the cell, DNA, the epigenome, the sirtuens and the information theory of aging, he also questions the implications of people on the planet growing older and starts a bold chapter of the political and societal futures, taking into consideration climate change and the divide between rich and poor.
It is strictly not a self help book even though insights can be glanced from it. Well known ideas are confirmed: exercise and eat your greens, but the more interesting part is where light is shed on the benefits of (intermittent) fasting, something that is currently regarded as a diet trend or fad. He also reveals some of the science around taking cold showers or the Wim Hof method. Much like fasting without starving, exposure to cold without catching a cold triggers the body and activates survival genes in our DNA and keeps us young at the level of the cell.
The book's chapters are concluded with chats between Sinclair and LaPlante, a colleague, in which they review the chapter in an informal podcast-like way and LaPlante questions Sinclair about the remarkable things he says. This serves both as a way to jog the remembrance of the content as well as keeping things light.
What I take away from this book is a renewed commitment to taking things easy, loving life and going for a triple digits chronological age. And a sort of "Todo" to investigate my genome, reread about the important chemicals and see what changes I can make in my life to live more vitally. Even though I don't put on fat (lucky me), I probably eat too much. This book helps me imagine, with a funny example of Tom Cruise, that I can live long while staying young.
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- Rose Morris
- 09-08-21
Amazing! No need to fear infirmities of old age?
Exciting! No longer fear the infirmities of old age!? A radical paradime shift. His practical methods can give us a jumpstart now. But Aging itself is the " disease" to be researched. Dementia , arthritis, heart disease, cancer, and the rest, are only it's symptoms! We need to spend our research money and efforts on anti-aging science. Living Better not just longer, without the fear of the infirmities of old age!
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- Raitis Putnins
- 11-22-19
Everybody should read this at least once
Happy to see that somebody in the field takes time to educate and inform. Thank you
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- TheMogget
- 07-22-21
Read by the Author
This is an important book. Even if the science is new, thinking of ageing as a disease makes sense. The prediction of new therapies and longer lifespan is well defended, and we need to consider the consequences of that.
The best part was the actual science stuff and discussion of what that means. The low point is where it strays too far into politics, climate science, and social commentary. The main point is that longer lives are a good thing if we handle it well. The details were not helpful.
The book is read by the Author and I love that. The author appears on TV and podcasts and I recognize the voice. It also helps to hear the phrasing and cadence of the author, even if he isn't a perfect narrator.
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- Galina COS
- 11-02-20
Fascinating story of the research
I can't stop listening to this book : it is full of such interesting information, enlighment and optimis, lots of food for thoughts.
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- anthony esposito
- 02-16-20
Required reading
loved it, Sinclair opens the mind to what the possibilities are. makes one wonder if the establishment really wants to cure aging as a disease
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