This is conclusion of the mini-series!

In this episode, we uncover the question, is the "cholinergic anti-inflammatory reflex" nerves entirely vagal? The answer is not so straightforward. Building on good work by Davide Martelli and Robin McAllen, we uncover crucial role of the efferent arm of the reflex to "also" be sympathetic.

And at the end, we also talk about the importance of understanding the referral and implantation pathway and why we remain muted in the ability of neuromodulation for immune-inflammation to be uptaken widely anytime soon.

SKRAPS is your podcast, where we on your behalf explores unsaid, underappreciated and sometimes, untold stories of sparks of brilliance in science, technology and innovation.

Show Credits

• Created & Produced by: Arun Sridhar
• Editing: Arun Sridhar
• Sound design: Arun Sridhar & Swaminathan ThiruGnanaSambandam
• Sound mixing and mastering: Swaminathan ThiruGnanaSambandam

Social Media:

• Twitter: @PodcastSkraps
• LinkedIn: SKRAPS
• Arun's Twitter Feed

You can help us fund the production costs by donating as little as $5 or £5 or in any currency of your choice as a one time or a recurring payment HERE

With the set up of how vagus signalling was deduced by careful and meticulous experiments of Linda Watkins, who built on some amazing results from Hugo Besedovsky, we turn our attention to how the hypothesis moved from tackling acute inflammatory models (e.g. Sepsis) to chronic inflammatory models and disease conditions like Rheumatoid Arthritis.

We are joined by Tony Arnold, ex-CEO of SetPoint Medical and Dr. Paul-Peter Tak who pioneered the clinical trials in Rheumatoid Arthritis and Inflammatory Bowel Disease.

Also, we cover some shocking moral plaigiarism from Feinstein Institute and Dr. Kevin Tracey in managing their public image. We now know that he was not the single pioneer of the transition to Arthritis and IBD trials as the news media claims or potrays him to be. It actually had many people's hand, especially Paul-Peter Tak's.

SKRAPS is your podcast, where we on your behalf explores unsaid, underappreciated and sometimes, untold stories of sparks of brilliance in science, technology and innovation.

Show Credits

• Created & Produced by: Arun Sridhar
• Editing: Arun Sridhar
• Sound design: Arun Sridhar & Swaminathan ThiruGnanaSambandam
• Sound mixing and mastering: Swaminathan ThiruGnanaSambandam

Social Media:

• Twitter: @PodcastSkraps
• LinkedIn: SKRAPS
• Arun's Twitter Feed

You can help us fund the production costs by donating as little as $5 or £5 or in any currency of your choice as a one time or a recurring payment HERE

What happens in the vagus, stays in vagus?? Not with us at SKRAPS.

“Science Is a Team Sport”

If we truly mean this - I mean, really and truly mean that science is a group effort and not the effort of one person, let’s really dive in to this and embrace our opportunities to set the record straight. And I mean let’s start right now! 

As we endeavor to understand The Wanderer, we must also strive to understand the contributors - and not just the marquee names. We hope to shed light on the nerve, the possibilities, the history, and all of the major players - not just a solo artist. After all, as we near the end of another American football season, I think we can appreciate that Joe Montana was better because of Jerry Rice - Troy Aikman thrived with Michael Irvin, and Tom Brady is the GOAT because of his myriad weapons.

Let’s be true to our intent to make science a team sport and go beyond the lip service.

SKRAPS is your podcast, where we on your behalf explores unsaid, underappreciated and sometimes, untold stories of sparks of brilliance in science, technology and innovation.

Show Credits

• Created & Produced by: Arun Sridhar
• Editing: Arun Sridhar
• Sound design: Arun Sridhar & Swaminathan ThiruGnanaSambandam
• Sound mixing and mastering: Swaminathan ThiruGnanaSambandam

Social Media:

• Twitter: @PodcastSkraps
• LinkedIn: SKRAPS
• Arun's Twitter Feed

You can help us fund the production costs by donating as little as $5 or £5 or in any currency of your choice as a one time or a recurring payment HERE or you can buy us a coffee - here