Dr. Craig Walker and Terry Roberts discuss a new class of injectable cholesterol-lowering drugs called PCSK9 inhibitors. These medications provide an additional option for lowering LDL ("bad") cholesterol beyond statin therapy alone.

Dr. Walker explains how PCSK9 normally works to block the recycling of LDL receptors in the liver, preventing further removal of LDL from the bloodstream. Two PCSK9 inhibitor drugs, Repatha and Praluent, use monoclonal antibodies to bind to PCSK9 instead, allowing LDL receptors to function properly and clear more LDL.

Viewers will learn about the mechanism of action of PCSK9 inhibitors and how they can significantly reduce cardiovascular risk by optimizing cholesterol levels.


Key Points:

• Introduction of PCSK9 inhibitors as a new class of injectable cholesterol-lowering drugs
• Explanation of how the PCSK9 protein works to block LDL receptor recycling in the liver
• Mechanism of action of PCSK9 inhibitor monoclonal antibodies like Repatha and Praluent
• Ability of PCSK9 inhibitors to further lower LDL cholesterol beyond statin therapy alone
• Potential role in optimizing cholesterol management and reducing cardiovascular risk

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Join Dr. Craig Walker as he provides an in-depth look at cholesterol-lowering medications, with a focus on statins. In this informative discussion, Dr. Walker breaks down the science behind these life-saving drugs, explaining how they work to reduce cholesterol production and increase its removal from the body. Learn about the two main types of statins, their differences, and why they're crucial for heart health. Dr. Walker addresses common misconceptions, discusses potential side effects like muscle aches, and offers practical advice on managing them. Discover why there's no such thing as "too low" LDL cholesterol and how regular monitoring can help optimize your treatment. Whether you're currently taking statins or considering them, this video provides valuable insights into one of the most important tools in fighting cardiovascular disease.


Key points:
• Statins are the most common cholesterol-lowering medications
• They work by reducing cholesterol production and increasing its removal
• The biggest side effect of statins is increased life expectancy
• Muscle aches are a common side effect, but can often be managed
• There's no such thing as "too low" LDL cholesterol
• Regular blood tests are important for monitoring cholesterol levels
• Statins are generally safe and effective for most patients


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In this episode of Cardiovascular Matters, Dr. Craig Walker discusses the importance of regular preventative health screenings for men to assess risk factors and detect early signs of cardiovascular disease. He recommends basic blood tests to check cholesterol levels, inflammation markers, and overall health. Additional tests like calcium scoring of the heart arteries and treadmill stress tests can identify issues like plaque buildup and blocked vessels before symptoms appear.
Detecting problems early through screening allows lifestyle changes like diet, exercise and smoking cessation, as well as medications to lower cholesterol, blood pressure and inflammation. This prevents further disease progression and reduces the risk of future heart attacks and strokes. Dr. Walker shares stories of discovering severe but asymptomatic disease in young patients to emphasize the value of screening. He also outlines the different types of strokes and exams that can check for risks like blocked neck arteries. The podcast promotes the message that taking control of heart health through regular checkups and testing can add years to men's lives and keep them active.


Timestamps:
0:00-5:00 Introduction and family history importance
5:00-10:00 Recommended basic blood tests
10:00-13:00 Additional tests like calcium scoring
13:00-16:00 Types of strokes and how to check for risks
16:00-19:50 Importance of detecting peripheral artery disease
19:50-22:00 New medications that can help reverse disease
22:00-25:00 Story about discovering risk in young asymptomatic men
25:00-29:00 Importance of lifestyle changes plus medical treatment
29:00-32:00 Closing message on the value of preventative screening


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In this educational podcast, Dr. Walker discusses the latest research on a new class of diabetes drugs called SGLT2 inhibitors like Jardiance. He explains how these medications work by blocking glucose reabsorption in the kidneys, causing it to be excreted in urine. While initially developed and approved for diabetes, extensive clinical trials have shown SGLT2 inhibitors provide significant benefits for heart failure, kidney disease, and weight loss. Dr. Walker reviews the evidence demonstrating their ability to reduce mortality, heart failure episodes, and progression to end-stage kidney disease. He also discusses proper hygiene practices for patients experiencing sugar in the urine. If you want to learn more about how SGLT2 inhibitors are revolutionizing treatment of diabetes and related conditions, watch this informative discussion.

Keynotes: This educational podcast discusses how the diabetes medication class called SGLT2 inhibitors such as Jardiance work by blocking glucose reabsorption in the kidneys, causing it to be excreted in urine, and reviews the extensive evidence that they provide significant benefits for heart failure, kidney disease, weight loss, and reducing mortality.

Timestamps:
0:00-4:00 Introduction and how SGLT2 inhibitors work
4:00-8:00 Benefits for heart failure
8:00-12:00 Additional benefits and approvals for kidney disease and weight loss
12:00-14:00 Hygiene considerations and reducing kidney failure risk
14:00-End Q&A and conclusions

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In this episode of the Cardiovascular Matters podcast, host Dr. Craig Walker discusses the growing problem of obesity in America and revolutionary new medication options that are helping people safely and effectively lose weight. Dr. Walker explains how obesity increases the risk of heart disease, diabetes and other serious health conditions. He then outlines several new classes of drugs, including GLP-1 agonists, that work to control hunger and blood sugar levels while promoting weight loss. Medical device sales veteran and patient Terry Roberts shares his own positive experience using these medications. Listeners will learn about treatment options and get insight into safely and successfully managing their weight.


Key points:

• The health risks of obesity like heart disease, diabetes and joint problems
• New classes of drugs for weight loss like GLP-1 agonists
• How the drugs work to control hunger, blood sugar and promote weight loss
• Positive results seen in weight loss and cardiovascular outcomes
• Terry Roberts shares his success with the medication plan

Chapter Markers:
0:00-5:00 - Introduction and overview of topic
5:00-10:00 - Health risks of obesity like heart disease and diabetes
10:00-15:00 - Introduction to new classes of weight loss drugs like GLP-1 agonists
15:00-20:00 - How the drugs work to control hunger and blood sugar
20:00-25:00 - Positive results seen in weight loss and cardiovascular outcomes
25:00-30:00 - Terry Roberts shares his success with the medication plan
30:00-35:00 - Q&A and call to action for listeners considering treatment

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This podcast discusses obesity as a major health problem and explores new medical treatments that are safe, effective and help patients feel better. The host Dr. Craig Walker and guest Terry Roberts discuss causes of obesity, health risks, challenges with past treatments and promising new medications.

Terry Roberts provides context for the episode by noting the rising rates of obesity, especially in children. He introduces Dr. Walker as an expert in treating the whole patient and addressing root causes of health issues like obesity.

Dr. Walker explains obesity has many causes related to lifestyle like eating highly processed foods and lack of exercise, but some patients struggle to lose weight no matter their efforts. Genetic and physiological factors play a role in why weight is difficult for some to lose.

Dr. Walker outlines the various health problems and diseases linked to obesity like heart disease, hypertension, diabetes, sleep apnea and more. Being overweight also increases orthopedic problems and lowers quality of life.

Previous weight loss options had problems. Medications that blocked nutrient absorption caused diarrhea, and amphetamine-like drugs were addictive and unsuitable for long-term use. Invasive surgeries also had high risks and complications.

Terry Roberts shares his own weight loss journey with encouragement from Dr. Walker. Dr. Walker discusses new medications that help the body release fat cells more easily and make patients feel good, unlike past options. When combined with lifestyle changes, these new treatments can safely and effectively help patients lose weight and improve health.

Key points:

• Obesity rates are rising, especially in children and teenagers
• Obesity increases risks of heart disease, hypertension, diabetes and more
• Past weight loss treatments had poor safety profiles or caused unpleasant side effects
• New medications help the body release fat cells more readily and make patients feel good
• When combined with lifestyle changes, new medications can safely and effectively help patients lose weight and improve health

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In this episode of Cardiovascular Matters, Dr. Craig Walker discusses the post-procedure care and follow up for patients who have undergone treatments for venous disease. He covers different types of procedures like stenting of the iliac veins, removal of deep vein clots, and closure of superficial and perforator veins.

Dr. Walker explains the recovery process for each type of procedure. For iliac vein stenting, patients may experience some back pain that typically lasts less than a week. They are also prescribed antiplatelet drugs for at least 3 months. For deep vein clot removal, patients need to take anticoagulants like Xarelto for at least 6 months to a year to prevent clots from returning. Superficial and perforator vein closures have a very short recovery with just pressure applied after the procedure.

He stresses the importance of follow up care, especially for patients who underwent treatment for venous ulcers. Their wounds are checked the following week to ensure proper healing. Various wound dressings and skin substitutes can be used to help large ulcers close. All patients are advised to continue walking and focus on weight loss to prevent recurrence of venous disease.

Dr. Walker and Terry Roberts emphasize that venous disease is more prevalent than other conditions but often ignored. Post-procedure lifestyle changes and medication can help patients finally get relief from debilitating symptoms they may have suffered with for decades.

Key points:

- Recovery timelines for different venous procedures
- Medications prescribed after stenting, clot removal etc
- Importance of follow up checks for ulcer patients
- Ongoing lifestyle measures like compression stockings, exercise
- Impact of venous disease and relief it provides patients

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This episode of Cardiovascular Matters explores perforator veins and their role in non-healing leg ulcers with Dr. Craig Walker. Dr. Walker discusses how perforator veins connect deep and superficial leg veins, and how they can cause high pressure that prevents ulcer healing.

• Perforator veins are connections between deep and superficial leg veins
• They are important not to cause issues like deep vein thrombosis during treatments
• Large perforator veins can apply high pressure to skin and cause ulcer formation

Dr. Walker explains that even with compression stockings, leg elevation and other measures, ulcers may not heal if perforator veins are applying pressure. Historically, perforator veins were difficult to treat due to their small size, but new minimally invasive techniques like laser ablation have revolutionized treatment.

• Perforator veins can cause ulcers to persist even with compression and elevation
• Early treatments were challenging due to size of perforator veins
• Laser ablation uses a thin fiber that can accurately treat perforator veins

Dr. Walker demonstrates how laser ablation of perforator veins is performed using ultrasound guidance, numbing and a laser fiber thinner than a hair. Multiple burns along the vein permanently close it off. This often provides immediate relief and allows ulcers to finally heal.

• Laser ablation is performed with ultrasound guidance for accuracy
• Numbing is given to prevent pain from laser heat treatment
• Multiple burns along the vein length close it off to reduce pressure

If you or a loved one suffers from non-healing leg ulcers, especially if other treatments have failed, perforator vein evaluation and treatment may help. Contact Dr. Walker at Cardiovascular Institute of the South for a consultation.

• Non-healing leg ulcers could be from underlying perforator vein issues
• Evaluation and treatment with Dr. Walker may help ulcers finally heal
• Contact Cardiovascular Institute of the South for a consultation

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