Dr. Craig Walker and Terry Roberts discuss a new class of injectable cholesterol-lowering drugs called PCSK9 inhibitors. These medications provide an additional option for lowering LDL ("bad") cholesterol beyond statin therapy alone.

Dr. Walker explains how PCSK9 normally works to block the recycling of LDL receptors in the liver, preventing further removal of LDL from the bloodstream. Two PCSK9 inhibitor drugs, Repatha and Praluent, use monoclonal antibodies to bind to PCSK9 instead, allowing LDL receptors to function properly and clear more LDL.

Viewers will learn about the mechanism of action of PCSK9 inhibitors and how they can significantly reduce cardiovascular risk by optimizing cholesterol levels.


Key Points:

• Introduction of PCSK9 inhibitors as a new class of injectable cholesterol-lowering drugs
• Explanation of how the PCSK9 protein works to block LDL receptor recycling in the liver
• Mechanism of action of PCSK9 inhibitor monoclonal antibodies like Repatha and Praluent
• Ability of PCSK9 inhibitors to further lower LDL cholesterol beyond statin therapy alone
• Potential role in optimizing cholesterol management and reducing cardiovascular risk

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Join Dr. Craig Walker as he provides an in-depth look at cholesterol-lowering medications, with a focus on statins. In this informative discussion, Dr. Walker breaks down the science behind these life-saving drugs, explaining how they work to reduce cholesterol production and increase its removal from the body. Learn about the two main types of statins, their differences, and why they're crucial for heart health. Dr. Walker addresses common misconceptions, discusses potential side effects like muscle aches, and offers practical advice on managing them. Discover why there's no such thing as "too low" LDL cholesterol and how regular monitoring can help optimize your treatment. Whether you're currently taking statins or considering them, this video provides valuable insights into one of the most important tools in fighting cardiovascular disease.


Key points:
• Statins are the most common cholesterol-lowering medications
• They work by reducing cholesterol production and increasing its removal
• The biggest side effect of statins is increased life expectancy
• Muscle aches are a common side effect, but can often be managed
• There's no such thing as "too low" LDL cholesterol
• Regular blood tests are important for monitoring cholesterol levels
• Statins are generally safe and effective for most patients


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In this episode of Cardiovascular Matters, Dr. Craig Walker discusses the importance of regular preventative health screenings for men to assess risk factors and detect early signs of cardiovascular disease. He recommends basic blood tests to check cholesterol levels, inflammation markers, and overall health. Additional tests like calcium scoring of the heart arteries and treadmill stress tests can identify issues like plaque buildup and blocked vessels before symptoms appear.
Detecting problems early through screening allows lifestyle changes like diet, exercise and smoking cessation, as well as medications to lower cholesterol, blood pressure and inflammation. This prevents further disease progression and reduces the risk of future heart attacks and strokes. Dr. Walker shares stories of discovering severe but asymptomatic disease in young patients to emphasize the value of screening. He also outlines the different types of strokes and exams that can check for risks like blocked neck arteries. The podcast promotes the message that taking control of heart health through regular checkups and testing can add years to men's lives and keep them active.


Timestamps:
0:00-5:00 Introduction and family history importance
5:00-10:00 Recommended basic blood tests
10:00-13:00 Additional tests like calcium scoring
13:00-16:00 Types of strokes and how to check for risks
16:00-19:50 Importance of detecting peripheral artery disease
19:50-22:00 New medications that can help reverse disease
22:00-25:00 Story about discovering risk in young asymptomatic men
25:00-29:00 Importance of lifestyle changes plus medical treatment
29:00-32:00 Closing message on the value of preventative screening


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www.cardio.com