In this episode, Dr. Jill O'Donnell-Tormey, CEO and Director of Scientific Affairs at the Cancer Research Institute (CRI), discusses the fascinating history of cancer immunotherapy, recent breakthroughs, and the potential role of focused ultrasound in enhancing immunotherapy treatments. The conversation explores current challenges and opportunities in cancer immunotherapy, including the need for personalized treatment approaches and the promising potential of combining immunotherapy with other modalities like focused ultrasound. Dr. O'Donnell-Tormey explains key concepts such as checkpoint inhibitors and CAR T-cell therapy, making complex ideas accessible to listeners. Listeners will gain valuable insights into the collaborative efforts between CRI and the Focused Ultrasound Foundation, learning how this partnership is driving innovation in cancer treatment. Dr. O'Donnell-Tormey also reflects on her career achievements and the evolving landscape of cancer research. This episode offers a unique opportunity to learn from a leading expert in the field, providing a deeper understanding of the latest advancements in cancer immunotherapy and the potential for innovative technologies like focused ultrasound to improve treatment outcomes for cancer patients. For more information about CRI visit cancerresearch.org

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Join us for a compelling conversation with Beverly McGowan, a nurse practitioner whose life was dramatically impacted by essential tremor. Beverly takes us through her journey, from the first signs of tremor affecting her work to the debilitating effects on her personal life and hobbies. She describes the challenges of traditional treatments and her discovery of focused ultrasound as a potential solution. Beverly provides a vivid, firsthand account of the focused ultrasound procedure, detailing the process step-by-step and sharing her immediate, transformative results. Learn about her rapid recovery, the short-term side effects, and her triumphant return to both her career and beloved hobbies like photography. Now a dedicated advocate for focused ultrasound technology, Beverly discusses her experiences sharing her story with legislators and offers valuable insights for others considering this treatment. As she steps into her new role as a patient advocate with the Focused Ultrasound Foundation, Beverly's story serves as a beacon of hope for those struggling with essential tremor and showcases the promising future of this groundbreaking medical technology.

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Dr. Clifford Cho, a renowned surgical oncologist from the University of Michigan, joins us to discuss the revolutionary intersection of histotripsy and cancer immunotherapy. Histotripsy, a noninvasive focused ultrasound mechanism, is changing the landscape of cancer treatment by not only destroying tumors but also potentially boosting the body's immune response against cancer. Dr. Cho provides an in-depth look at the successful #HOPE4LIVER clinical trial, which demonstrated histotripsy's safety and efficacy in treating liver tumors. He explains how this technology works without heat or radiation, offering a precision treatment option for patients with limited alternatives. The conversation explores the unexpected benefits of histotripsy, including its ability to alter tumor blood vessel architecture and oxygen levels, potentially making cancers more vulnerable to treatment. The episode also covers the exciting future of focused ultrasound in cancer treatment. Dr. Cho shares his lab's ongoing research, including efforts to make traditionally immunotherapy-resistant cancers, like pancreatic cancer, more responsive to treatment. He discusses the expansion of histotripsy applications to other organs and the development of a new clinical-translational program, promising broader access to this innovative treatment and further advancements in cancer research.

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In this episode, Dr. Stavros Zanos, a renowned researcher at the Feinstein Institutes for Medical Research, discusses the potential of focused ultrasound neuromodulation in treating a wide range of cardiovascular and inflammatory diseases. Dr. Zanos explains how ultrasound activates neurons through mechanosensitive channels and shares the promising results of recent studies using neuromodulation to treat pulmonary arterial hypertension, reduce inflammatory markers, and potentially manage type 2 diabetes. Learn about the importance of precision in ultrasound neuromodulation to ensure accurate targeting of specific areas in the abdomen. This episode offers a fascinating glimpse into the future of medicine, where focused ultrasound neuromodulation could significantly impact the treatment of millions of patients worldwide.

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Dr. Daniel Jeanmonod, a renowned functional neurosurgeon, joins us upon his retirement to reflect on his pioneering career. Since 1989, Dr. Jeanmonod has been at the forefront of focused ultrasound research and treatment for neuropathic pain, Parkinson's disease, and essential tremor. He recounts his groundbreaking achievement in using noninvasive focused ultrasound to treat patients at the University Children's Hospital of Zurich. He also discusses the establishment of the SoniModul Center of Ultrasound Functional Neurosurgery in Zurich and the center's impressive track record over its 14-year history. Dr. Jeanmonod shares fascinating patient stories that highlight the profound impact of focused ultrasound treatments on individuals suffering from chronic, therapy-resistant neuropathic pain. He also emphasizes the importance of considering the psycho-emotional aspects of pain management and the role of psychotherapy in optimizing treatment outcomes. Throughout the conversation, Dr. Jeanmonod offers valuable advice for young neurosurgeons interested in using focused ultrasound in functional neurosurgery. He stresses the significance of understanding the underlying mechanisms of brain disorders.

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This episode features an insightful discussion on the potential of focused ultrasound in revolutionizing women's health care. The conversation, moderated by Dr. Jessica Foley, Chief Scientific Officer at the Focused Ultrasound Foundation, includes expert panelists Dr. Suzanne LeBlang, neuroradiologist and Director of Clinical Relationships at the Focused Ultrasound Foundation, Dr. Lynn Dengel, surgical oncologist at UVA Health, and Dr. Elisa Konofagou, professor of biomedical engineering and radiology at Columbia University. The discussion highlights the versatility of focused ultrasound in treating a wide range of conditions that disproportionately affect women, such as uterine fibroids, breast tumors, Alzheimer's disease, chronic pain, depression, and anxiety. The panelists share their experiences and research in using focused ultrasound for various applications, including ablation, immunotherapy, neuromodulation, and opening the blood-brain barrier for drug delivery. The experts also address the challenges faced in advancing focused ultrasound for women's health, including the need for more clinical trials with female participants, raising awareness among clinicians and patients, and securing insurance coverage. They emphasize the importance of collaboration among researchers, clinicians, and regulatory bodies to accelerate the translation of focused ultrasound technologies from bench to bedside. This engaging discussion offers valuable insights into the current state and future potential of focused ultrasound in improving the lives of women affected by a variety of health conditions. The episode also highlights the Focused Ultrasound Foundation's efforts in supporting research, fostering collaboration, and advocating for focused ultrasound as a transformative tool in women's health care.

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Chuck Walker, an adventurer and business owner, began experiencing symptoms of Parkinson’s disease in 2013. In this episode, Chuck and his wife, Dr. Maureen Whelihan, share their inspiring journey with focused ultrasound treatment. Chuck shares how his Parkinson’s-related tremor affected his daily life, from running and riding motorcycles to giving presentations at work, and how medications fell short in managing his condition. Chuck and Maureen discuss their journey in learning about and deciding to participate in a clinical trial for bilateral focused ultrasound treatment. The couple walks us through the treatment process, the remarkable results, and the immediate improvements in Chuck's symptoms. They also touch on the emotional impact of the treatment, with Chuck regaining his dignity and confidence in both his personal and professional life. They emphasize the importance of clinical trials in advancing treatments like focused ultrasound therapy and express gratitude for the organizations and donors making these innovations possible. This inspiring episode showcases the power of focused ultrasound therapy in improving the lives of those living with Parkinson's disease, offering hope and encouragement to others who may qualify for this innovative treatment option for their symptoms.

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In this episode of Curing with Sound, Dr. Jessica Foley, the Chief Scientific Officer and a Managing Director at the Focused Ultrasound Foundation, discusses her journey in the biomedical field, from her early interest in math and science to the groundbreaking work in focused ultrasound. Dr. Foley holds a Bachelor of Science in Biomedical Engineering from Duke University and a PhD in Bioengineering from the University of Washington, with an emphasis on focused ultrasound. Throughout the conversation, Dr. Foley shares her unique experience as a fellow for the American Association for the Advancement of Science and how it has shaped her career in science policy and advocacy. She reflects on the highlights of her career, including being present for the first essential tremor patients treated with focused ultrasound, a pivotal moment that has since led to over 10,000 patients receiving treatment worldwide.

Dr. Foley expresses her excitement about the future of focused ultrasound and its versatile applications, from enhancing drug delivery and inducing anti-cancer immune responses to neuromodulation for treating depression, anxiety, and substance use disorders. As the Chief Scientific Officer at the Focused Ultrasound Foundation, she plays a multifaceted role in advancing the field through research funding, advocacy, and government affairs. She emphasizes the importance of raising awareness about focused ultrasound, increasing its availability, and addressing the challenges of insurance coverage to ensure equitable access for patients. Dr. Foley also touches on her experience as a woman in the biotech field and offers advice for the next generation of women in science and engineering. Dr. Foley encourages listeners who are passionate about focused ultrasound to reach out and collaborate with the Foundation in breaking down barriers and moving the field forward.

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