• New Insight: A Look at Gildeuretinol (ALK-001) for Stargardt Disease w/ Seemi Khan, MD

  • Jul 2 2024
  • Length: 21 mins
  • Podcast

New Insight: A Look at Gildeuretinol (ALK-001) for Stargardt Disease w/ Seemi Khan, MD

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  • Summary

  • In the latest episode of New Insight with Veeral Sheth, MD, host Veeral Sheth, MD, director of clinical research at University Retina, speaks with Seemi Khan, chief medical officer at Alkeus Pharmaceuticals, on the company’s lead candidate being evaluated in clinical trials for the treatment of Stargardt disease and geographic atrophy (GA) secondary to age-related macular degeneration (AMD).

    Gildeuretinol is a novel molecule designed as a specialized form of deuterated vitamin A to reduce the dimerization of vitamin A without disrupting vision. The therapy has received Breakthrough and Orphan Drug designations from the US Food and Drug Administration (FDA).

    Listen to the conversation between experts on Khan’s background in the pharmaceutical industry, including time spent at Abbott, Abbvie, and Quark Pharmaceuticals, her experience bringing treatments to patients with rare diseases, and the impressive data from gildeuretinol in the TEASE clinical trial program for a currently unmet need.

    Episode Highlights
    0:07     Episode Intro
    0:57 Seemi Khan's background
    4:38 Mechanism of action of gildeuretinol
    7:22 Patient populations
    9:00 TEASE clinical trial program
    14:37 Gildeuretinol in GA
    16:32 Safety data
    18:47 Next steps for Alkeus
    22:28 Conclusion

    Check out more ophthalmology coverage at HCPLive.com!
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