Featuring an interview with Dr Matthew R Smith, including the following topics:

• Selection and sequencing of androgen-targeting therapies (0:00)
• Evidence-based selection of treatment for metastatic hormone-sensitive prostate cancer (25:07)
• New considerations with the use of PARP inhibitors for metastatic castration-resistant prostate cancer (mCRPC) (27:44)
• Role of novel radiopharmaceuticals for mCRPC (37:09)
• Promising investigational approaches for prostate cancer (42:38)

CME information and select publications

Featuring an interview with Dr Kimberly H Allison, including the following topics:

• Contemporary practices in pathology and reporting biomarkers of interest (0:00)
• HER2 testing across numerous solid tumor types (2:47)
• ER-low reporting category and pathologic interpretation (6:28)
• PD-1/PD-L1 testing methodology and challenges with bone biopsies (10:53)

CME information and select publications

Featuring a slide presentation and related discussion from Dr Kimberly H Allison, including the following topics:

• Pathological assessment of HER2 and appropriate testing methodologies (0:00)
• Effect of the DESTINY-Breast04 study on clinical practice (12:32)
• Relevancy of HER2-ultralow expression and implications of the DESTINY-Breast06 study (22:53)
• Future directions in the pathological and clinical assessment of HER2-positive breast cancer (31:06)

CME information and select publications