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Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research. Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing - atom by atom - both a new life-saving immunosuppressant drug and a drug to combat the virus that causes AIDS.

By the summer of 1941, in the ninth year of his presidency, Franklin Roosevelt had molded his Court. He had appointed seven of the nine justices—the most by any president except George Washington—and handpicked the chief justice. But the wartime Roosevelt Court had two faces. One was bold and progressive, the other supine and abject, cowed by the charisma of the revered president. The Court at War explores this pivotal period.

DeLillo's Running Dog, originally published in 1978, follows Moll Robbins, a New York City journalist trailing the activities of an influential senator. In the process, she is dragged into the black market world of erotica and shady, infatuated men, where a cat-and-mouse chase for an erotic film rumored to “star” Adolph Hitler leads to trickery, maneuvering, and bloodshed. With streamlined prose and a thriller's narrative pace, Running Dog is a bright star in the modern master's early career.

For Blood and Money tells the little-known story of how an upstart biotechnology company created a one-in-a-million cancer drug and how the core team—denied their share of the profits—went and did it again. In this epic saga of money and science, veteran financial journalist Nathan Vardi explains how the invention of two of the biggest cancer drugs in history became (for their backers) two of the greatest Wall Street bets of all time.

The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity - by chewing, brewing, and snorting - some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the 5,000-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze Age medicine, a worm-killing birch fungus, knotted to his leggings.

Few were ready when a mysterious respiratory illness emerged in Wuhan, China, in January 2020. Politicians, government officials, business leaders, and public-health professionals were unprepared for the most devastating pandemic in a century. Many of the world’s biggest drug and vaccine makers were slow to react or couldn’t muster an effective response. It was up to a small group of unlikely and untested scientists and executives to save civilization.

Beginning in the 1970s, several scientific breakthroughs promised to transform the creation of new medicines. As investors sought to capitalize on these Nobel Prize-winning discoveries, the biotech industry grew to thousands of small companies around the world. Each sought to emulate what the major pharmaceutical companies had been doing for a century or more, but without the advantages of scale, scope, experience, and massive resources. From Breakthrough to Blockbuster focuses on both the companies themselves and the broader biotech ecosystem that supports them.

The vibrant economy of the new Vietnam is a shiny lure for Western capital. Companies are racing to uncover ideal opportunities. Not wanting to be left behind, Hendley Associates has sent their best analyst, Jack Ryan, Jr., to mine for investment gold. And he may have found some in a rare earth mining company—GeoTech. But a trip with a Hendley colleague to the Highlands to observe the company’s operations takes a treacherous turn when their helicopter is shot down. Some things haven’t changed, and Vietnam is still the plaything of powerful neighbors.

In the last half of the twentieth century, Don Thomas discovered a cure for every marrow-based disease—like leukemia, lymphoma, and sickle-cell anemia—forever changing treatment for some of the deadliest illnesses. His feats were extraordinary, earning him a Nobel Prize, and the cascade of treatments he inspired have reshaped and will continue to reshape the practice of clinical medicine. Yet no one has ever written Thomas’s courageous story.Dr. Frederick R. Appelbaum, a member of Thomas’s research team, does so for the first time.

Originally written in Icelandic in the 13th century AD by an anonymous author, The Story of The Volsungs is a legendary saga based on Norse mythology. The epic describes the legendary history and heroic feats of several generations of mythic Viking families and derives from many sources, including preexisting Edda, or heroic poems, Norse legends, historical events, and orally transmitted folklore. The saga is imbued throughout with themes of power, jealousy, love, vengeance, and fear.

The Big Miss is Hank Haney's candid and surprisingly insightful account of his tumultuous six-year journey with Tiger Woods, during which the supremely gifted golfer collected six major championships and rewrote golf history. Hank was one of the very few people allowed behind the curtain. He was with Tiger 110 days a year, spoke to him over 200 days a year, and stayed at his home up to 30 days a year, observing him in nearly every circumstance....

In 1989, the charismatic Joshua Boger left Merck, then America's most admired business, to found a drug company that would challenge industry giants and transform health care. Barry Werth described the company's tumultuous early days during the AIDS crisis in The Billion-Dollar Molecule, a celebrated classic of science and business journalism. Now he returns to tell a riveting story of Vertex's bold endurance and eventual success.

Working Backwards is a practical guidebook and a corporate narrative, filled with the authors’ in-the-room recollections of what “Being Amazonian” is like and how it has affected their personal and professional lives. They demonstrate that success on Amazon’s scale is not achieved by the genius of any single leader, but rather through commitment to and execution of a set of well-defined, rigorously executed principles and practices - shared here for the very first time.

April 2011: On a remote mountaintop overlooking the remains of the Iranian nuclear weapons program, Azad Ashani witnesses a Quds Force demonstration of a capability meant to upend America’s war in the Middle East. Ashani, director of the Iranian Ministry of Intelligence and Security and Irene Kennedy’s former back channel to the Iranian government, recognizes the demonstration’s true significance, and the nation-ending conflict it will provoke. Alone, Ashani stands no chance of preventing this rush to madness.

Today, PayPal’s founders and earliest employees are considered the technology industry’s most powerful network. Since leaving PayPal, they have formed, funded, and advised the leading companies of our era, including Tesla, Facebook, YouTube, SpaceX, Yelp, Palantir, and LinkedIn, among many others. As a group, they have driven 21st-century innovation and entrepreneurship. Their names stir passions; they’re as controversial as they are admired.

No matter your goals, Atomic Habits offers a proven framework for improving - every day. James Clear, one of the world's leading experts on habit formation, reveals practical strategies that will teach you exactly how to form good habits, break bad ones, and master the tiny behaviors that lead to remarkable results. If you're having trouble changing your habits, the problem isn't you. The problem is your system. Bad habits repeat themselves again and again not because you don't want to change, but because you have the wrong system for change.

No matter who you’re talking to, The Next Conversation gives you immediately actionable strategies and phrases that will forever change how you communicate. Jefferson Fisher, trial lawyer and one of the leading voices on real-world communication, offers a tried-and-true framework that will show you how to transform your life and your relationships by improving your next conversation.

Mel Robbins is back! The international bestselling phenomenon and creator of The Five Second Rule and Kick Ass with Mel Robbins returns to help you tackle the single biggest obstacle you face: fear. This life-changing Audible Original features a powerful mix of one-on-one life-coaching sessions and a personal narrative with vital take-aways that you can start using immediately.

You can go after the job you want...and get it! You can take the job you have...and improve it! You can take any situation you're in...and make it work for you!

Coexisting but conflicting needs create self-sabotaging behaviors. This is why we resist efforts to change, often until they feel completely futile. But by extracting crucial insight from our most damaging habits, building emotional intelligence by better understanding our brains and bodies, releasing past experiences at a cellular level, and learning to act as our highest potential future selves, we can step out of our own way and into our potential.

What is that magic quality that makes some people instantly loved and respected? Everyone wants to be their friend (or, if single, their lover!) In business, they rise swiftly to the top of the corporate ladder. What is their "Midas touch?"

Stephen R. Covey's book, The 7 Habits of Highly Effective People, has been a top seller for the simple reason that it ignores trends and pop psychology for proven principles of fairness, integrity, honesty, and human dignity. Celebrating its 15th year of helping people solve personal and professional problems, this special anniversary edition includes a new foreword and afterword written by Covey that explore whether the 7 Habits are still relevant and answer some of the most common questions he has received over the past 15 years.

An updated edition of the blockbuster best-selling leadership book that took America and the world by storm, two US Navy SEAL officers who led the most highly decorated special operations unit of the Iraq War demonstrate how to apply powerful leadership principles from the battlefield to business and life.

Robert Greene is a master guide for millions of listeners, distilling ancient wisdom and philosophy into essential texts for seekers of power, understanding, and mastery. Now he turns to the most important subject of all - understanding people's drives and motivations, even when they are unconscious of them themselves. Whether at work, in relationships, or in shaping the world around you, The Laws of Human Nature offers brilliant tactics for success, self-improvement, and self-defense.

Legendary leadership and elite performance expert Robin Sharma introduced The 5am Club concept more than 20 years ago, based on a revolutionary morning routine that has helped his clients maximize their productivity, activate their best health and bulletproof their serenity in this age of overwhelming complexity. Now, in this life-changing guide, handcrafted by the author over a rigorous four-year period, you will discover the early-rising habit that has helped so many accomplish epic results while upgrading their happiness, helpfulness, and feelings of aliveness.

Can’t Hurt Me, David Goggins’ smash hit memoir, demonstrated how much untapped ability we all have but was merely an introduction to the power of the mind. In Never Finished, Goggins takes you inside his Mental Lab, where he developed the philosophy, psychology, and strategies that enabled him to learn that what he thought was his limit was only his beginning and that the quest for greatness is unending.

Why is Miami… Miami? What does the heartbreaking fate of the cheetah tell us about the way we raise our children? Why do Ivy League schools care so much about sports? What is the Magic Third, and what does it mean for racial harmony? In this provocative new work, Malcolm Gladwell returns to the subject of social epidemics and tipping points, this time with the aim of explaining the dark side of contagious phenomena. Through a series of gripping stories, Gladwell traces the rise of a new and troubling form of social engineering

James Clear nos brinda fantásticas ideas basadas en investigaciones científicas, que le permiten revelarnos cómo podemos transformar pequeños hábitos cotidianos para cambiar nuestra vida y mejorarla. Esta guía pone al descubierto las fuerzas ocultas que moldean nuestro comportamiento - desde nuestra mentalidad, pasando por el ambiente y hasta la genética - y nos demuestra cómo aplicar cada cambio a nuestra vida y a nuestro trabajo. Después de leer este libro, tendrás un método sencillo para desarrollar un sistema eficaz que te conducirá al éxito.

Come inside a jury room as one juror leads a starkly divided room to consensus. Join a young CIA officer as he recruits a reluctant foreign agent. And sit with an accomplished surgeon as he tries, and fails, to convince yet another cancer patient to opt for the less risky course of treatment. In Supercommunicators, Charles Duhigg blends deep research and his trademark storytelling skills to show how we can all learn to identify and leverage the hidden layers that lurk beneath every conversation.

Think and Grow Rich is the number-one inspirational and motivational classic for individuals who are interested in furthering their lives and reaching their goals by learning from important figures in history. The text read in this audiobook is the original 1937 edition written by Napoleon Hill and inspired by Andrew Carnegie - and while it has often been reproduced, no updated version has ever been able to compete with the original.

The government is a vast, complex system that Americans pay for, rebel against, rely upon, dismiss, and celebrate. It’s also our shared resource for addressing the biggest problems of society. And it’s made up of people, mostly unrecognized and uncelebrated, doing work that can be deeply consequential and beneficial to everyone. Michael Lewis invited his favorite writers to find someone doing an interesting job for the government and write about them in a special in-depth series for the Washington Post.

We live in a world that’s obsessed with talent. We celebrate gifted students in school, natural athletes in sports, and child prodigies in music. But admiring people who start out with innate advantages leads us to overlook the distance we ourselves can travel. We underestimate the range of skills that we can learn and how good we can become. We can all improve at improving. And when opportunity doesn’t knock, there are ways to build a door.

The guru to the gurus at last shares his knowledge with the rest of us. Nobel laureate Daniel Kahneman's seminal studies in behavioral psychology, behavioral economics, and happiness studies have influenced numerous other authors, including Steven Pinker and Malcolm Gladwell. In Thinking, Fast and Slow, Kahneman at last offers his own, first book for the general public. It is a lucid and enlightening summary of his life's work. It will change the way you think about thinking. Two systems drive the way we think and make choices, Kahneman explains....

Author of the New York Times and international best-seller Unfu*k Yourself Gary John Bishop presents a no-holds-barred guide to breaking through our cycles of self-sabotage to get what we want out of life.

Will Guidara was twenty-six when he took the helm of Eleven Madison Park, a struggling two-star brasserie that had never quite lived up to its majestic room. Eleven years later, EMP was named the best restaurant in the world. How did Guidara pull off this unprecedented transformation? Radical reinvention, a true partnership between the kitchen and the dining room—and memorable, over-the-top, bespoke hospitality.